New ribosomes for new memories?
New ribosomes for new memories?
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DOI：
10.1080/19420889.2015.1017163
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发表时间：
2015-03
影响因子：
--
通讯作者：
Allen KD
中科院分区：
文献类型：
--
作者：
Hernández AI;Alarcon JM;Allen KD
rRNA的调控和合成被广泛认为是一个内务管理过程，是维持突触可塑性和记忆的潜在核心机制。我们最近的研究表明，后期突触可塑性的一个重要组成部分是rRNA生物合成——新核糖体产生的限速步骤。我们假设，在学习相关的神经活动中产生了特定的核糖体群，以改变标记突触中可塑性因子的合成速率，从而支持突触可塑性和记忆的维持。
Widely thought to be a housekeeping process, the regulation and synthesis of rRNA emerges as a potentially central mechanism for the maintenance of synaptic plasticity and memory. We have recently shown that an essential component of late-phase synaptic plasticity is rRNA biosynthesis — the rate-limiting step in the production of new ribosomes. We hypothesize that a particular population of ribosomes is generated upon learning-associated neural activity to alter the rate of synthesis of plasticity factors at tagged synapses that will support the maintenance of synaptic plasticity and memory.