Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals.
Mass-spectrometric characterization of peroxidized and hydrolyzed lipids in plasma and dendritic cells of tumor-bearing animals.
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DOI：
10.1016/j.bbrc.2011.08.074
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发表时间：
2011-09-16
影响因子：
3.1
通讯作者：
Kagan, Valerian E.
中科院分区：
文献类型：
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作者：
Tyurin, Vladimir A.;Cao, Wei;Tyurina, Yulia Y.;Gabrilovich, Dmitry I.;Kagan, Valerian E.
关键词：
树突状细胞是负责癌症中免疫应答发展的最有效的抗原呈递细胞。然而，已知树突状细胞在荷瘤宿主中的功能严重受损。我们以前的研究表明，树突状细胞功能的缺陷在很大程度上是由于大量脂质（主要是甘油三酯）在荷瘤小鼠和癌症患者的相当大比例的树突状细胞中的积累。树突状细胞的脂质积累可能与其清道夫受体A的上调有关。该受体主要负责摄取修饰的脂质。在这里，通过使用不同版本的液相色谱质谱法，我们确定了几种分子种类的含氧脂质在荷瘤动物的血浆中，可能是负责他们的摄取和积累的树突状细胞通过清道夫受体A依赖性途径的影响，可能与树突状细胞的免疫监视功能在癌症中的损失。
Dendritic cells are the most potent antigen presenting cells responsible for the development of immune responses in cancer. However, it is known that the function of dendritic cells in tumor-bearing hosts is severely compromised. Our previous studies demonstrated that the defects in dendritic cell function are due, to a large extent, to the accumulation of high amounts of lipids – predominantly triglycerides – in a substantial proportion of dendritic cells in tumor-bearing mice and patients with cancer. The dendritic cells accumulation of lipids is likely associated with their up-regulation of a scavenger receptor A. This receptor is primarily responsible for uptake of modified lipids. Here, by using different versions of liquid-chromatography mass-spectrometry, we identified several molecular species of oxygenated lipids in plasma of tumor-bearing animals that may be responsible for their uptake and accumulation by dendritic cells via scavenger receptor A-dependent pathway – the effect that may be associated with the loss of dendritic cell's immune surveillance function in cancer.
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影响因子：
82.9
作者：
通讯作者：
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癌症中的脂质积累和树突状细胞功能障碍
影响因子：
82.9
作者：
Herber, Donna L.;Cao, Wei;Gabrilovich, Dmitry I.
通讯作者：
Gabrilovich, Dmitry I.
影响因子：
4.8
作者：
Davis, Bill;Koster, Grielof;Postle, Anthony D.
通讯作者：
Postle, Anthony D.
DOI：
10.1007/978-1-60327-029-8_21
发表时间：
2010-01-01
期刊：
FREE RADICALS AND ANTIOXIDANT PROTOCOLS, SECOND EDITION
影响因子：
--
作者：
Tyurin, Vladimir A.;Tyurina, Yulia Y.;Kagan, Valerian E.
通讯作者：
Kagan, Valerian E.