Incidence of Malignancies in Patients with IgG4-related Disease
Incidence of Malignancies in Patients with IgG4-related Disease
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DOI：
10.2169/internalmedicine.53.1342
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发表时间：
2014-01-01
影响因子：
1.2
通讯作者：
Koike, Kazuhiko
中科院分区：
文献类型：
--
作者：
Hirano, Kenji;Tada, Minoru;Koike, Kazuhiko
目的探讨包括自身免疫性胰腺炎(AIP)在内的IgG4相关疾病(IgG4-RD)是否与恶性肿瘤有关，但目前尚不清楚。方法对113例IgG4-RD发病时未诊断为恶性且随访时间超过6个月的患者进行分析。共有95名患者接受AIP治疗。平均随访期为73个月。结果15例恶性肿瘤患者中，肺癌5例，胰腺癌2例，胃癌2例，胆管癌1例，肾癌1例，乳腺癌1例，舌癌1例，恶性黑色素瘤1例，急性髓系白血病1例。计算的总恶性肿瘤标化发病率为1.04(95%可信区间0.57~1.75)，差异无统计学意义。结论IgG4-RD患者总恶性肿瘤发病率与一般人群相似。目前，有理由得出结论，IgG4-RD与总恶性肿瘤发病率的增加无关。
Objective It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified.Methods We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age-and sex-matched general Japanese population based on the Vital Statistics of Japan.Results There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75).Conclusion The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies.