Association of KCNJ11 with impaired glucose regulation in essential hypertension.
Association of KCNJ11 with impaired glucose regulation in essential hypertension.
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DOI：
10.4238/vol10-2gmr1127
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发表时间：
2011-06
期刊：
影响因子：
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通讯作者：
Y. Wang;X. Zhou;Y. Zhang;P. Gao;D. Zhu
中科院分区：
文献类型：
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作者：
Y. Wang;X. Zhou;Y. Zhang;P. Gao;D. Zhu
KCNJ11是2型糖尿病的候选基因之一，已被全基因组关联研究证实，但关于KCNJ11与原发性高血压患者血糖调节受损的关系的数据很少。为了确定 KCNJ11 基因中的 E23K 和 I337V 对血糖调节受损易感性的影响，我们对 1125 名中国汉族人群中患有或不患有血糖调节受损的原发性高血压患者进行了一项病例对照研究。我们还评估了两种 SNP 对通过口服葡萄糖耐量试验估计的胰岛素敏感性和葡萄糖耐量的影响。在我们的病例对照研究中，使用任何基因型模型均未发现 E23K 和 I337V 与葡萄糖调节受损之间存在关联。然而，E23K 的赖氨酸携带者显示出与胰岛素（30 分钟）和 Cederholm 指数下降显着相关，I337V 的缬氨酸携带者显示出与较低的 Cederholm 指数相关。所有定量测试均通过线性回归进行，并调整性别、年龄、体重指数、血压和血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂治疗。这些发现提供了证据表明KCNJ11基因在原发性高血压患者胰岛素敏感性降低的发病机制中发挥作用。
KCNJ11 is one of the candidate genes for type 2 diabetes, confirmed by genome wide association study, but there are little data on the relationship between KCNJ11 and impaired glucose regulation in essential hypertension patients. To identify the effect of E23K and I337V in the KCNJ11 gene on susceptibility to impaired glucose regulation, we conducted a case control study in 1125 essential hypertension patients with or without impaired glucose regulation among a Han Chinese population. We also evaluated the impact of two SNPs on insulin sensitivity and glucose tolerance estimated through an oral glucose tolerance test. In our case control study, no association of E23K and I337V with impaired glucose regulation was found using any genotypic models. However, lysine carriers of E23K showed a significant association with decreased insulin (30 min) and Cederholm index, and valine carriers of I337V showed association with a lower Cederholm index. All the quantitative tests were performed by linear regression, with adjustment for gender, age, body mass index, blood pressure, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker treatment. These findings provided evidence that the KCNJ11 gene plays a role in the pathogenesis of decreased insulin sensitivity in essential hypertension patients.