STAT signaling in the pathogenesis and treatment of myeloid malignancies.
STAT signaling in the pathogenesis and treatment of myeloid malignancies.
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DOI：
10.4161/jkst.20006
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发表时间：
2012-04-01
期刊：
影响因子：
--
通讯作者：
Frank DA
中科院分区：
文献类型：
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作者：
Bar-Natan M;Nelson EA;Xiang M;Frank DA
STAT转录因子在介导细胞因子对骨髓细胞的作用中起关键作用。由于STAT靶基因控制关键过程，如存活、增殖和自我更新，因此STAT，特别是STAT3和STAT5的组成性激活是许多骨髓肿瘤中的常见事件并不奇怪。STAT被突变酪氨酸激酶以及其他致病事件激活，并且STAT的持续激活在对激酶抑制剂的抗性的情况下是常见的。因此，单独或与其他药物联合靶向STAT可能对癌症治疗具有越来越重要的意义。
STAT transcription factors play a critical role in mediating the effects of cytokines on myeloid cells. As STAT target genes control key processes such as survival, proliferation and self-renewal, it is not surprising that constitutive activation of STATs, particularly STAT3 and STAT5, are common events in many myeloid tumors. STATs are activated both by mutant tyrosine kinases as well as other pathogenic events, and continued activation of STATs is common in the setting of resistance to kinase inhibitors. Thus, the targeting of STATs, alone or in combination with other drugs, will likely have increasing importance for cancer therapy.