The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines.
The Role of G Protein-Coupled Receptors (GPCRs) and Calcium Signaling in Schizophrenia. Focus on GPCRs Activated by Neurotransmitters and Chemokines.
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DOI：
10.3390/cells10051228
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发表时间：
2021-05-17
期刊：
影响因子：
6
通讯作者：
Zylinska L
中科院分区：
文献类型：
--
作者：
Boczek T;Mackiewicz J;Sobolczyk M;Wawrzyniak J;Lisek M;Ferenc B;Guo F;Zylinska L
精神分裂症是一种常见的使人衰弱的疾病，其特征是持续或复发的精神病发作。尽管这种精神疾病的分子机制尚不完全清楚，但越来越多的临床、药理学和遗传学证据表明，G蛋白偶联受体（gpcr）在疾病的发生、进展和治疗中起着关键作用。gpcr是抗精神病药物最常见的靶标，这一事实进一步强调了这一关键作用。gpcr的激活通过几个下游途径引起缓慢的突触传递，其中许多途径参与细胞内Ca2+动员。涉及gpcr在额叶和边缘相关区域的作用的神经递质系统功能障碍可能是包括阳性和阴性精神分裂症症状的整个谱系的复杂图景的基础。因此，我们对gpcr在控制大脑认知功能中的作用的理解的进展有望为选择性药物的开发开辟新的途径。在本文中，我们回顾并综合了最近关于神经递质- gpcr信号传导对精神分裂症症状的贡献的数据。
Schizophrenia is a common debilitating disease characterized by continuous or relapsing episodes of psychosis. Although the molecular mechanisms underlying this psychiatric illness remain incompletely understood, a growing body of clinical, pharmacological, and genetic evidence suggests that G protein-coupled receptors (GPCRs) play a critical role in disease development, progression, and treatment. This pivotal role is further highlighted by the fact that GPCRs are the most common targets for antipsychotic drugs. The GPCRs activation evokes slow synaptic transmission through several downstream pathways, many of them engaging intracellular Ca2+ mobilization. Dysfunctions of the neurotransmitter systems involving the action of GPCRs in the frontal and limbic-related regions are likely to underly the complex picture that includes the whole spectrum of positive and negative schizophrenia symptoms. Therefore, the progress in our understanding of GPCRs function in the control of brain cognitive functions is expected to open new avenues for selective drug development. In this paper, we review and synthesize the recent data regarding the contribution of neurotransmitter-GPCRs signaling to schizophrenia symptomology.
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影响因子：
3.4
作者：
Baisley, Sarah K;Fallace, Katherine L;Rajbhandari, Abha K;Bakshi, Vaishali P
通讯作者：
Bakshi, Vaishali P
影响因子：
3.7
作者：
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影响因子：
4.5
作者：
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通讯作者：
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DOI：
10.1017/s1461145704004110
发表时间：
2004-03-01
影响因子：
4.8
作者：
Abi-Dargham, A
通讯作者：
Abi-Dargham, A
影响因子：
3.4
作者：
Arnsten, AFT
通讯作者：
Arnsten, AFT