Paradigms of endothelial stiffening in cardiovascular disease and vascular aging.
Paradigms of endothelial stiffening in cardiovascular disease and vascular aging.
复制标题
心血管疾病和血管衰老中内皮僵硬的范例。
DOI：
10.3389/fphys.2022.1081119
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发表时间：
2022
影响因子：
4
通讯作者：
Levitan, Irena
中科院分区：
文献类型：
--
作者：
Aguilar, Victor M. M.;Paul, Amit;Lazarko, Dana;Levitan, Irena
Endothelial cells, the inner lining of the blood vessels, are well-known to play a critical role in vascular function, while endothelial dysfunction due to different cardiovascular risk factors or accumulation of disruptive mechanisms that arise with aging lead to cardiovascular disease. In this review, we focus on endothelial stiffness, a fundamental biomechanical property that reflects cell resistance to deformation. In the first part of the review, we describe the mechanisms that determine endothelial stiffness, including RhoA-dependent contractile response, actin architecture and crosslinking, as well as the contributions of the intermediate filaments, vimentin and lamin. Then, we review the factors that induce endothelial stiffening, with the emphasis on mechanical signals, such as fluid shear stress, stretch and stiffness of the extracellular matrix, which are well-known to control endothelial biomechanics. We also describe in detail the contribution of lipid factors, particularly oxidized lipids, that were also shown to be crucial in regulation of endothelial stiffness. Furthermore, we discuss the relative contributions of these two mechanisms of endothelial stiffening in vasculature in cardiovascular disease and aging. Finally, we present the current state of knowledge about the role of endothelial stiffening in the disruption of endothelial cell-cell junctions that are responsible for the maintenance of the endothelial barrier.
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影响因子：
3.4
作者：
Ayee, Manuela A. A.;LeMaster, Elizabeth;Levitan, Irena
通讯作者：
Levitan, Irena
影响因子：
--
作者：
Belvitch P;Htwe YM;Brown ME;Dudek S
通讯作者：
Dudek S
影响因子：
3.4
作者：
Ayee, Manuela Aseye Ayele;LeMaster, Elizabeth;Levitan, Irena
通讯作者：
Levitan, Irena
影响因子：
4.8
作者：
Carraher, Cara L.;Schwarzbauer, Jean E.
通讯作者：
Schwarzbauer, Jean E.
影响因子：
2.4
作者：
Byfield FJ;Reen RK;Shentu TP;Levitan I;Gooch KJ
通讯作者：
Gooch KJ