Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients
Proton spectroscopy study of the left dorsolateral prefrontal cortex in pediatric depressed patients
复制标题
DOI：
10.1016/j.neulet.2005.04.099
复制
发表时间：
2005-08-26
影响因子：
2.5
通讯作者：
Soares, JC
中科院分区：
文献类型：
--
作者：
Caetano, SC;Fonseca, M;Soares, JC
背外侧前额叶皮层（DLPFC）在重度抑郁症（MDD）异常的情绪调节和认知功能整合中起着重要作用。很少有神经影像学研究评估抑郁症儿童和青少年仍在成熟的DLPFC。我们对14名抑郁症儿童和青少年（13.3 +/- 12.3岁，10名男性）和22名匹配的健康对照（13.6 +/- 2.8岁，13名男性）进行了左DLPFC的单体素质子磁共振波谱（H-1 MRS）检测。与健康对照组相比，抑郁受试者左侧DLPFC的甘油磷酸胆碱加磷酸胆碱（GPC + PC；或含胆碱化合物）水平显著降低，肌醇水平较高。在抑郁受试者中，我们发现谷氨酸水平与疾病持续时间和发作次数之间存在显著的负相关。在健康对照中，年龄和谷氨酰胺水平之间存在显著的直接相关性，而在患者组中不存在这种相关性。儿童MDD中GPC + PC水平较低可能反映DLPFC中每体积细胞膜含量较低。MDD患者肌醇水平升高可能代表次级信使系统受到干扰。GPC + PC和肌醇异常进一步证明DLPFC参与儿童MDD。2005爱思唯尔爱尔兰有限公司版权所有。
The dorsolateral prefrontal cortex (DLPFC) plays an essential role in mood regulation and integration of cognitive functions that are abnormal in major depressive disorder (MDD). Few neuroimaging studies have evaluated the still maturing DLPFC in depressed children and adolescents. We conducted single voxel proton magnetic resonance spectroscopy (H-1 MRS) of the left DLPFC in 14 depressed children and adolescents (13.3 +/- 12.3 years old, 10 males) and 22 matched healthy controls (13.6 +/- 2.8 years old, 13 males). Depressed subjects had significantly lower levels of glycerophosphocholine plus phosphocholine (GPC + PC; or choline-containing compounds) and higher myo-inositol levels in the left DLPFC compared to healthy controls. In the depressed subjects, we found significant inverse correlations between glutamate levels and both duration of illness and number of episodes. In healthy controls there was a significant direct correlation between age and glutamine levels, which was not present in the patient group. Lower GPC + PC levels in pediatric MDD may reflect lower cell membrane content per volume in the DLPFC. Increased myo-inositol levels in MDD may represent a disturbed secondary messenger system. GPC + PC and myo-inositol abnormalities further demonstrate the involvement of DLPFC in pediatric MDD. (c) 2005 Elsevier Ireland Ltd. All rights reserved.