Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes
Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes
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DOI：
10.1056/nejm199610313351802
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发表时间：
1996-10-31
影响因子：
158.5
通讯作者：
Braunwald, E
中科院分区：
文献类型：
--
作者：
Antman, EM;Tanasijevic, MJ;Braunwald, E
背景：在急性冠脉综合征患者中，寻找一种与心肌损害程度密切相关、可提供预后信息且可快速检测的敏感血清标志物是可取的。我们研究了心肌肌钙蛋白I水平在不稳定型心绞痛和非Q波型心肌梗死患者中的预后价值。方法在一项多中心研究中，对1404例有症状的患者的血液标本进行了检测，心肌肌钙蛋白I是健康人血液中未检测到的一种血清标志物。结果573例心肌肌钙蛋白I水平<0.4 ng/毫升的患者42天死亡率(21例死亡，3.7%)显著高于心肌肌钙蛋白I<0.4 ng/毫升的831例患者(8例死亡，1.0%；P
Background In patients with acute coronary syndromes, it is desirable to identify a sensitive serum marker that is closely related to the degree of myocardial damage, provides prognostic information, and can be measured rapidly. We studied the prognostic value of cardiac troponin I levels in patients with unstable angina or non-Q-wave myocardial infarction.Methods In a multicenter study, blood specimens from 1404 symptomatic patients were analyzed for cardiac troponin I, a serum marker not detected in the blood of healthy persons. The relation between mortality at 42 days and the level of cardiac troponin in the specimen obtained on enrollment was determined both before and after adjustment for base-line characteristics.Results The mortality rate at 42 days was significantly higher in the 573 patients with cardiac troponin I levels of at least 0.4 ng per milliliter (21 deaths, or 3.7 percent) than in the 831 patients with cardiac troponin I levels below 0.4 ng per milliliter (8 deaths, or 1.0 percent; P