Validation of the Cough Quality-of-Life Questionnaire in Patients With Idiopathic Pulmonary Fibrosis
Validation of the Cough Quality-of-Life Questionnaire in Patients With Idiopathic Pulmonary Fibrosis
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DOI：
10.1378/chest.12-2870
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发表时间：
2013-06-01
期刊：
影响因子：
9.6
通讯作者：
Horton, Maureen R.
中科院分区：
文献类型：
--
作者：
Lechtzin, Noah;Hilliard, Marisa E.;Horton, Maureen R.
背景：咳嗽是特发性肺纤维化（IPF）的一种普遍和致残性症状，是疾病进展的一个独立预测因子。咳嗽生活质量问卷（CQLQ）是一种经验证的咳嗽特异性生活质量指标，可用作IPF治疗试验的结局指标。本研究旨在评估CQLQ的可靠性和有效性在个人与IPF.Methods：CQLQ管理作为一个结果在先前发表的27周，安慰剂对照，交叉试验沙利度胺治疗IPF咳嗽。参与者为患有IPF和慢性咳嗽的成人。咳嗽视觉模拟量表（VAS）和圣乔治呼吸问卷（SGRQ）进行管理，以建立同时效度的CQLQ.Results：内部一致性高（克朗巴赫α>.70）的CQLQ总分和六个分量表得分的四个。CQLQ总分与咳嗽VAS评分、SGRQ总分和子量表评分显著相关，证明了CQLQ总分的同时有效性（r范围为0.63-0.81; P
Background: Cough is a pervasive and disabling symptom of idiopathic pulmonary fibrosis (IPF) and is an independent predictor of disease progression. The Cough Quality-of-Life Questionnaire (CQLQ) is a validated measure of cough-specific quality of life that could be used as an outcome measure in therapeutic trials for IPF. This study aimed to assess the reliability and validity of the CQLQ in individuals with IPF.Methods: The CQLQ was administered as an outcome within a previously published 27-week, placebo-controlled, crossover trial of thalidomide for cough in IPF. Participants were adults with IPF and chronic cough. A cough visual analog scale (VAS) and the St. George's Respiratory Questionnaire (SGRQ) were administered to establish concurrent validity of the CQLQ.Results: Internal consistency was high (Cronbach alpha>.70) for the CQLQ total and four of six subscale scores. The CQLQ total score demonstrated concurrent validity through significant correlations with scores on the cough VAS and SGRQ total and subscale scores (r range, 0.63-0.81; P