Catalytic Asymmetric Synthesis of [2,3]- Fused Indoline Heterocycles through Inverse- Electron- Demand Aza- Diels- Alder Reaction of Indoles with Azoalkenes
Catalytic Asymmetric Synthesis of [2,3]- Fused Indoline Heterocycles through Inverse- Electron- Demand Aza- Diels- Alder Reaction of Indoles with Azoalkenes
复制标题
吲哚与偶氮烯的反电子需求氮杂狄尔斯-阿尔德反应催化不对称合成[2,3]-稠合吲哚啉杂环
DOI：
10.1002/anie.201400109
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发表时间：
2014-04-25
影响因子：
16.6
通讯作者：
Wang, Chun-Jiang
中科院分区：
文献类型：
--
作者：
Tong, Min-Chao;Chen, Xuan;Wang, Chun-Jiang
报道了吲哚与原位生成的偶氮烯烃的催化不对称反电子需求aza-Diels-桤木反应。以通常良好的产率（高达97%）和高的区域选择性和非对映选择性（>20：1 d.r.）获得了一组不同的[2，3]-稠合吲哚啉杂环，并且具有优异的对映选择性（高达99%ee）。
An unprecedented catalytic asymmetric inverse-electron-demand aza-Diels-Alder reaction of indoles with insitu formed azoalkenes is reported. A diverse set of [2,3]-fused indoline heterocycles were achieved in generally good yields (up to 97%) with high regioselectivity and diastereoselectivity (>20:1 d.r.), and with excellent enantioselectivity (up to 99% ee).