Dynamic contrast enhanced MRI of prostate cancer: Correlation with morphology and tumour stage, histological grade and PSA
Dynamic contrast enhanced MRI of prostate cancer: Correlation with morphology and tumour stage, histological grade and PSA
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DOI：
10.1053/crad.1999.0327
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发表时间：
2000-02-01
影响因子：
2.6
通讯作者：
Husband, JE
中科院分区：
文献类型：
--
作者：
Padhani, AR;Gapinski, CJ;Husband, JE
目的：为了量化正常和异常前列腺组织的MRI增强特征，并将这些与肿瘤分期，组织学分级和肿瘤markers.MATERIALS和方法：定量梯度回波MR图像获得后团注钆喷酸葡胺48例前列腺癌。在相同的解剖位置的快速自旋回波T2加权图像进行了审查的存在肿瘤（45个区域），正常外周带（33个区域）和正常出现的中央腺（30个区域），时间-信号强度参数（起始时间、平均梯度和最大增强幅度以及洗脱评分）和建模参数（渗透表面积乘积、病变渗漏空间和最大钆浓度）与肿瘤分期、组织学分级相关（Gleason评分）和血清前列腺特异性抗原（PSA）水平。外周区和肿瘤之间的信号强度和建模参数（P = 0.0001），除了发病时间的显着差异。MRI肿瘤分期与肿瘤血管通透性（r（2）= 12%; P = 0.02）和肿瘤最大钆浓度（r（2）= 14%; P = 0.015）之间存在弱相关性。然而，没有显着的相关性被认为与Gleason评分或PSA levels.CONCLUSION：量化的MR对比增强特征允许在前列腺癌的组织歧视与已知的微血管密度估计的变化一致。Padhani，A. R.等（2000）。(C)2000年皇家放射科医师学院。
AIM: To quantify MRI enhancement characteristics of normal and abnormal prostatic tissues and to correlate these with tumour stage, histological grade and tumour markers.MATERIALS AND METHODS: Quantitative gradient recalled echo MR images were obtained following bolus injection of gadopentetate dimeglumine in 48 patients with prostate cancer. Turbo spin-echo T2-weighted images at the same anatomical position were reviewed for the presence of tumours (45 regions), normal peripheral zone (33 regions), and normal appearing central gland (30 regions), Time-signal intensity parameters (onset time, mean gradient and maximal amplitude of enhancement and wash-out score) and modelling parameters (permeability surface area product, lesion leakage space and maximum gadolinium concentration) were correlated with tumour stage, histological grade (Gleason score) and serum prostatic specific antigen (PSA) levels.RESULTS: Significant differences were noted between peripheral zone and tumour with respect to signal intensity and modelling parameters (P = 0.0001), except onset time. No differences between central gland and tumour enhancement values were seen, There was weak correlation between MRI tumour stage and tumour vascular permeability (r(2) = 12%; P = 0.02) and maximum tumour gadolinium concentration (r(2) = 14%; P = 0.015). However, no significant correlations were seen with Gleason score or PSA levels.CONCLUSION: Quantification of MR contrast enhancement characteristics allows tissue discrimination in prostate cancer consistent with known variations in microvessel density estimates. Padhani, A. R. et al. (2000). (C) 2000 The Royal College of Radiologists.