Infection due to 3 Avian influenza subtypes in United States veterinarians
Infection due to 3 Avian influenza subtypes in United States veterinarians
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DOI：
10.1086/518579
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发表时间：
2007-07-01
影响因子：
11.8
通讯作者：
Gray, Gregory C.
中科院分区：
文献类型：
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作者：
Myers, Kendall P.;Setterquist, Sharon F.;Gray, Gregory C.
背景大流行性流感病毒株起源于禽类。我们检查了美国的兽医以前的禽流感病毒感染的证据。我们使用2002年至2004年收集的血清样本，在42名兽医和66名健康对照受试者中进行了对照、横断面血清阳性率研究。采用微量中和试验检测血清样品对9株甲型流感病毒的敏感性。使用多变量逻辑回归模型，与对照组相比，暴露于禽类的兽医对H5、H6和H7禽流感病毒分离株的滴度在统计学上显著升高。这些数据表明，职业接触禽类可能会增加兽医感染禽流感病毒的风险。在大流行规划中，应考虑兽医优先获得疫苗和抗病毒药物。
Background. Pandemic influenza virus strains originate in avian species. We examined veterinarians in the United States for evidence of previous avian influenza virus infection.Methods. We performed a controlled, cross-sectional seroprevalence study among 42 veterinarians and 66 healthy control subjects using serum samples collected from 2002 through 2004. Serum samples were tested using a microneutralization assay against 9 influenza A virus strains.Results. Using multivariable logistic regression modeling, veterinarians exposed to birds demonstrated statistically significant elevated titers against the H5, H6, and H7 avian influenza virus isolates, compared with control subjects.Conclusions. These data suggest that occupational exposure to avian species may increase veterinarians' risk of avian influenza virus infection. Veterinarians should be considered for priority access to vaccines and antiviral drugs in pandemic planning.