Plasma Folate Concentrations Are Positively Associated with Risk of Estrogen Receptor β Negative Breast Cancer in a Swedish Nested Case Control Study
Plasma Folate Concentrations Are Positively Associated with Risk of Estrogen Receptor β Negative Breast Cancer in a Swedish Nested Case Control Study
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DOI：
10.3945/jn.110.124313
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发表时间：
2010-09-01
影响因子：
4.2
通讯作者：
Wirfalt, Elisabet
中科院分区：
文献类型：
--
作者：
Ericson, Ulrika;Borgquist, Signe;Wirfalt, Elisabet
叶酸在乳腺癌发展中的作用是有争议的。不仅雌激素受体（ER）α状态，而且ER β状态的肿瘤可能会混淆结果从以前的流行病学研究。我们的目的是研究血浆叶酸浓度与绝经后乳腺癌（ER状态）之间的关系。在马尔莫饮食和癌症队列中，这项巢式病例对照研究包括204例乳腺癌病例，这些病例的ER α和ER β状态通过组织微阵列切片上的免疫化学测定。分析了病例和408名对照（年龄和血样日期匹配）的血浆叶酸浓度。采用非条件Logistic回归分析计算ER定义的乳腺癌患者血浆叶酸浓度三分位数的比值比（OR）。所有测试均为双侧测试。血浆叶酸浓度第三个三分位数（>12 nmol/L）的女性ER β-乳腺癌的发病率高于第一个三分位数的女性（OR：2.67; 95% CI：1.44-4.92; P趋势= 0.001）。我们没有观察到血浆叶酸浓度与ER状态定义的其他乳腺癌亚组之间的显著相关性。我们观察到ER β +和ER β-癌症风险之间的差异（P-异质性= 0.003）。我们的研究结果表明，血浆叶酸和ER β-乳腺癌之间存在正相关，强调了在叶酸和乳腺癌研究中考虑ER β状态的重要性。这项研究有助于了解叶酸在癌症发展中的多方面作用。如果在其他人群中复制，观察结果可能对公共卫生产生影响，特别是关于叶酸强化。J.营养140：1661-1668，2010.
Folate's role in breast cancer development is controversial. Not only estrogen receptor (ER) alpha status, but also ER beta status of tumors may have confounded results from previous epidemiological studies. We aimed to examine associations between plasma folate concentration and postmenopausal breast cancer defined by ER status. This nested case-control study, within the Malmo diet and cancer cohort, included 204 incident breast cancer cases with information on ER alpha and ER beta status determined by immunochemistry on tissue micro-array sections. Plasma folate concentration was analyzed for the cases and 408 controls (matched on age and blood sample date). Odds ratios (OR) for ER-defined breast cancers in tertiles of plasma folate concentration were calculated with unconditional logistic regression. All tests were 2-sided. Women in the third tertile of plasma folate concentration (>12 nmol/L) had higher incidence of ER beta- breast cancer than women in the first tertile (OR: 2.67; 95% CI: 1.44-4.92; P-trend = 0.001). We did not observe significant associations between plasma folate concentration and other breast cancer subgroups defined by ER status. We observed a difference between risks for ER beta+ and ER beta- cancer (P-heterogeneity = 0.003). Our findings, which indicate a positive association between plasma folate and ER beta- breast cancer, highlight the importance of taking ER beta status into consideration in studies of folate and breast cancer. The study contributes knowledge concerning folate's multifaceted role in cancer development. If replicated in other populations, the observations may have implications for public health, particularly regarding folic acid fortification. J. Nutr. 140: 1661-1668, 2010.