Oxygen and renal metabolism
Oxygen and renal metabolism
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DOI：
10.1038/ki.1997.50
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发表时间：
1997-02-01
影响因子：
19.6
通讯作者：
Epstein, FH
中科院分区：
文献类型：
--
作者：
Epstein, FH
哺乳动物肾脏供氧的最大特点是其不均一性。每分钟流向肾脏的血液总量与肾脏的重量相比是很高的。整个肾脏的氧摄取率如此之低，混合肾静脉血的含氧量如此之高，以至于人们经常认为，在正常情况下，肾脏细胞有充足的氧气来执行他们的工作。然而，这种供应的大部分流向肾皮质，在那里它最大限度地依赖于流动清除废物。相比之下，流向肾髓质的血流量较少。如表1[1]所示，肾髓质的氧气供应仅略高于其对氧气的利用。肾脏显著的供氧不均衡性对肾脏病理生理学和疾病有重要意义[1-3]。
The most striking feature of the oxygen supply to the mamma-lian kidney is its inhomogeneity. The total flow of blood to the kidney per minute is high in relation to its weight. Oxygen extraction across the kidney is so low and mixed renal venous blood so oxygenated that it is often assumed that under normal circumstances kidney cells are plentifully supplied with more than enough oxygen to perform their work. However, the bulk of this supply is directed to the renal cortex, where it maximizes flowdependent clearance of wastes. By contrast, blood flow to the renal medulla is parsimonious. The supply of 02 to the renal medulla barely exceeds its 02 utilization, as illustrated in Table 1 [1]. The striking inhomogeneity of oxygen supply that character-izes the kidney has important implications for renal pathophysi-ology and disease [1—3].