Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.
Wireless deep-brain neuromodulation using photovoltaics in the second near-infrared spectrum.
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DOI：
10.1016/j.device.2023.100113
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发表时间：
2023-10
期刊：
影响因子：
--
通讯作者：
Han Cui;Su Zhao;Guosong Hong
中科院分区：
文献类型：
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作者：
Han Cui;Su Zhao;Guosong Hong
传统的电神经调节技术受到神经组织侵入性植入的限制，而使用光遗传学的方法则受到遗传改变的影响，并受到可见光组织穿透性差的阻碍。利用第二近红外（NIR-II）光谱的光进行光伏神经调节，可以最大限度地减少散射并增强组织穿透，有望成为现有神经调节技术的替代方案。NIR-II光已被用于深部组织成像和通过纳米换能器进行深部脑光热神经调节。这一观点概述了光伏神经调节的基本机制，并确定了未来材料科学和生物工程研究的途径，可以进一步推进NIR-II光伏神经调节方法。
Conventional electrical neuromodulation techniques are constrained by the need for invasive implants in neural tissues, whereas methods using optogenetics are subjected to genetic alterations and hampered by the poor tissue penetration of visible light. Photovoltaic neuromodulation using light from the second near-infrared (NIR-II) spectrum, which minimizes scattering and enhances tissue penetration, shows promise as an alternative to existing neuromodulation technologies. NIR-II light has been used in deep-tissue imaging and in deep-brain photothermal neuromodulation via nanotransducers. This perspective provides an overview for the underpinning mechanisms of photovoltaic neuromodulation and identifies avenues for future research in materials science and bioengineering that can further advance NIR-II photovoltaic neuromodulation methods.