Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver.
Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver.
复制标题
新型大鼠 G 蛋白偶联受体基因的分子克隆，该基因在肺、肾上腺和肝脏中显着表达。
DOI：
10.1016/0014-5793(93)81318-t
复制
发表时间：
1993
期刊：
影响因子：
3.5
通讯作者：
Lynch,KR
中科院分区：
文献类型：
--
作者：
Harrison,JK;Barber,CM;Lynch,KR
A gene and cDNA (named G10d) encoding a novel member of the G‐protein‐coupled receptor (GCR) superfamily has been isolated from a rat genomic library and a rat liver cDNA library by tandom polymerase chain reaction (PCR) amplification and hybridization screening. Comparison of the sequence of the encoded protein to other members of the rhodopsin family of the GCR superfamily suggests that this new member is a peptide receptor. The G10d gene is present as a single copy in the rat genome and its translational open reading frame is intronless. Northern analysis demonstrates a wide and uneven distribution of G10d mRNA in the adult rat, with the highest mRNA abundance in lung, liver and adrenal gland extracts.
