Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma.
Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma.
复制标题
术前血小板-淋巴细胞比值作为软组织肉瘤的预后因素优于中性粒细胞-淋巴细胞比值。
DOI：
10.1186/s12885-015-1654-6
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发表时间：
2015-10-02
期刊：
影响因子：
3.8
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Que Y;Qiu H;Li Y;Chen Y;Xiao W;Zhou Z;Zhang X
炎症可以促进肿瘤生长、侵袭、血管生成甚至转移。炎症标志物已被确定为各种恶性肿瘤的预后指标。本研究比较了血小板-淋巴细胞比率（PLR）和嗜中性粒细胞-淋巴细胞比率（NLR）在预测软组织肉瘤（STS）根治性切除术患者预后方面的作用。我们在这项回顾性研究中纳入了222例STS患者。采用Kaplan-Meier曲线和多变量考克斯比例模型计算总生存期（OS）和无病生存期（DFS）。在单因素分析中，PLR和NLR升高均与OS降低显著相关。在多因素分析中，PLR（HR：2.60; 95%CI：1.17-5.74，P = 0.019）而非NLR仍被确定为结局的独立预测因子。高PLR组和低PLR组的中位OS分别为62个月和76个月。在单变量分析中，高PLR和NLR均与较短的DFS显著相关，高PLR和低PLR组的中位DFS分别为18和57个月。在多变量分析中，PLR升高（HR：1.77; 95% CI：1.05-2.97，P = 0.032）也与DFS降低相关。本研究为STS的诊断和监测提供了新的有价值的线索。疾病进展的预测不仅通过使用临床或组织病理学因素（包括肿瘤分级、肿瘤大小和肿瘤部位）来确定，而且还通过宿主反应因素（如体能状态、体重减轻和全身炎症反应）来确定。它们也会显著影响临床结果。因此，PLR可用于增强临床诊断。此外，PLR可以从常规可用的外周血测试中评估，而无需任何其他复杂的支出，从而为测量提供更低的成本和更大的便利。术前PLR升高作为一个独立的预后因素，在预测STS患者的临床结局方面优于NLR上级。本文的在线版本（doi：10.1186/s12885-015-1654-6）包含补充材料，可供授权用户使用。
Inflammation can promote tumor growth, invasion, angiogenesis and even metastasis. Inflammatory markers have been identified as prognostic indicators in various malignances. This study compared the usefulness of platelet-lymphocyte ratio (PLR) with that of neutrophil-lymphocyte ratio (NLR) for predicting outcomes of patients who underwent radical resection for soft tissue sarcoma (STS). We included 222 STS patients in this retrospective study. Kaplan-Meier curves and multivariate Cox proportional models were used to calculate overall survival (OS) and disease free survival (DFS). In univariate analysis, elevated PLR and NLR were both significantly associated with decreased OS. In multivariate analysis, PLR (HR: 2.60; 95 % CI: 1.17–5.74, P = 0.019) but not NLR was still identified as independent predictors of outcome. Median OS was 62 and 76 months for the high PLR and low PLR groups, respectively. High PLR and NLR were both significantly associated with shorter DFS in univariate analysis, with median DFS of 18 and 57 months in the high PLR and low PLR groups. In multivariate analysis, elevated PLR (HR: 1.77; 95 % CI: 1.05–2.97, P = 0.032) was also related to decreased DFS. Our findings provide a new and valuable clue for diagnosing and monitoring STS. Prediction of disease progression is not only determined by the use of clinical or histopathological factors including tumor grade, tumor size, and tumor site but also by host-response factors such as performance status, weight loss, and systemic inflammatory response. They also significantly affect clinical outcomes. Thus, PLR can be used to enhance clinical prognostication. Furthermore, the PLR can be assessed from peripheral blood tests that are routinely available without any other complicated expenditure, thus providing lower cost and greater convenience for the prognostication. Elevated preoperative PLR as an independent prognostic factor is superior to NLR in predicting clinical outcome in patients with STS. The online version of this article (doi:10.1186/s12885-015-1654-6) contains supplementary material, which is available to authorized users.