Causal Network Inference for Neural Ensemble Activity.

Causal Network Inference for Neural Ensemble Activity.
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神经集成活动的因果网络推理。

DOI:
10.1007/s12021-020-09505-4
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发表时间:
2021-07
期刊:
影响因子:
3
通讯作者:
Chen R
Chen R
中科院分区:
医学4区
文献类型:
--
作者:
Chen R

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Interactions among cellular components forming a mesoscopic scale brain network (microcircuit) display characteristic neural dynamics. Analysis of microcircuits provides a system-level understanding of the neurobiology of health and disease. Causal discovery aims to detect causal relationships among variables based on observational data. A key barrier in causal discovery is the high dimensionality of the variable space. A method called Causal Inference for Microcircuits (CAIM) is proposed to reconstruct causal networks from calcium imaging or electrophysiology time series. CAIM combines neural recording, Bayesian network modeling, and neuron clustering. Validation experiments based on simulated data and a real-world reaching task dataset demonstrated that CAIM accurately revealed causal relationships among neural clusters.
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