ROLE OF ENDOTHELIUM-DERIVED NITRIC-OXIDE IN THE ABNORMAL ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION OF PATIENTS WITH ESSENTIAL-HYPERTENSION
ROLE OF ENDOTHELIUM-DERIVED NITRIC-OXIDE IN THE ABNORMAL ENDOTHELIUM-DEPENDENT VASCULAR RELAXATION OF PATIENTS WITH ESSENTIAL-HYPERTENSION
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DOI：
10.1161/01.cir.87.5.1468
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发表时间：
1993-05-01
期刊：
影响因子：
37.8
通讯作者：
QUYYUMI, AA
中科院分区：
文献类型：
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作者：
PANZA, JA;CASINO, PR;QUYYUMI, AA
背景原发性高血压患者存在异常的内皮依赖性血管舒张功能。由于内皮细胞通过释放几种物质对血管平滑肌发挥作用，因此重要的是要确定哪些因素参与了高血压动脉的异常反应。为了研究内皮源性一氧化氮在这种异常中的作用，我们研究了精氨酸类似物N（G）-单甲基-L-精氨酸（一种内皮合成一氧化氮的抑制剂）在基线条件下和输注乙酰胆碱（一种内皮依赖性血管扩张剂）和硝普钠（一种直接平滑肌扩张剂）期间的血管效应。该研究包括11名高血压患者（7名男性;年龄，46.5+/-9岁）和10名正常对照受试者（7名男性;年龄，45.7+/-7岁）。将药物注入肱动脉，并通过应变计体积描记术测量前臂血管的反应。正常对照组和高血压患者的基础血How相似（2.97 ± 0.7 vs 2.86 ± 1.1 mL）。min-1。100 mL-1）。N（G）-单甲基-L-精氨酸在对照受试者中产生的血流量下降显著大于患者（1.08+/-0.6 vs 0.32+/-0.4 mL）。min-1。100 mL-1; p < 0.004）。与对照受试者相比，患者对乙酰胆碱的血管扩张反应降低（最大流量，8.2+/-4 vs 16.4+/-8 mL。min-1。100 mL-1; p
Background. Patients with essential hypertension have abnormal endothelium-dependent vasodilation. Because the endothelium exerts its action on the vascular smooth muscle through the release of several substances, it is important to identify which of these factors is involved in the abnormal response of hypertensive arteries.Methods and Results. To investigate the role of endothelium-derived nitric oxide in this abnormality, we studied the vascular effect of the arginine analogue N(G)-monomethyl-L-arginine, an inhibitor of the endothelial synthesis of nitric oxide, under baseline conditions and during infusion of acetylcholine, an endothelium-dependent vasodilator, and sodium nitroprusside, a direct smooth muscle dilator. The study included 11 hypertensive patients (seven men; age, 46.5+/-9 years) and 10 normal control subjects (seven men; age, 45.7+/-7 years). Drugs were infused into the brachial artery, and the response of the forearm vasculature was measured by strain-gauge plethysmography. Basal blood How was similar in normal control subjects and hypertensive patients (2.97+/-0.7 versus 2.86+/-1.1 mL . min-1 . 100 mL-1, respectively). N(G)-monomethyl-L-arginine produced a significantly greater decrease in blood flow in control subjects than in patients (1.08+/-0.6 versus 0.32+/-0.4 mL . min-1 . 100 mL-1; p < 0.004). The vasodilator response to acetylcholine was reduced in patients compared with control subjects (maximum flow, 8.2+/-4 versus 16.4+/-8 mL . min-1 . 100 mL-1; p