Generation and delivery of free hydroxyl radicals using a remote plasma
Generation and delivery of free hydroxyl radicals using a remote plasma
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DOI：
10.1088/1361-6595/acb07f
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发表时间：
2023-01-01
影响因子：
3.8
通讯作者：
Maguire, P. D.
中科院分区：
文献类型：
--
作者：
McQuaid, H. N.;Rutherford, D.;Maguire, P. D.
我们展示了一种新的基于气体的OH中心点生成源，使用低功率射频驱动的大气压等离子体，配置为将自由基通量传递到远流出区域，远离其他等离子体因素（如电场，电流和紫外线辐射）的干扰。使用从实验室空气中分离的He-H2O气体化学，等离子体产生的通量包含OH中心点和其它自由基，包括O和HO 2以及H2 O2，发现其沿着随H2O蒸气含量和吸收功率密度而变化。在距离等离子体50 mm处，H2 O2和OH中心点的峰值通量值分别为2.3 nmol s（-1）和0.23 nmol s（1），H2O为790 ppmv，功率密度类似于10（8）W m-3。最大OH中心点通量密度为4.5 × 10（19）m（-2）s（-1），在110 mm处下降到1.7 × 10（19）m（2）s（1），相当于74 μ M s（1）和28 μ M s（-1）的产生速率。尽管在等离子体出口处的高OH中心点复合率，逃逸通量仍然是显著的，表明到下游目标的可行的递送能力。它的性能方面的OH中心点的产生率相比，以及与传统的OH中心点的产生技术，如辐解，先进的氧化工艺和增强的芬顿化学方法，其中OH中心点的生产率是亚μ M s（-1）。传递精确可量化的OH（中心点）通量为细胞生物学、大气化学、蛋白质展开和基于血浆的系统剂量研究以及其他OH中心点相关的潜在医学治疗提供了新的科学研究机会和技术机会。
We demonstrate a new gas-based OH center dot generation source using a low power radio frequency driven atmospheric pressure plasma configured to deliver the radical flux into the far effluent region, well away from interference from other plasma factors such as electric fields, currents, and ultraviolet radiation. Using He-H2O gas chemistry isolated from the laboratory air, the plasma generated flux contains OH center dot and other radicals including, O and HO2 as well as H2O2 which, along with, was found to vary with H2O vapour content and absorbed power density. Peak flux values were 2.3 nmol s(-1) and 0.23 nmol s(1) for H2O2 and OH center dot respectively at a distance of 50 mm from the plasma, with 790 ppmv H2O and a power density of similar to 10(8) W m-3. The maximum OH center dot flux density was 4.5 x 10(19) m(-2) s(-1) falling to 1.7 x 10(19) m(2) s(1) at 110 mm, equivalent to generation rates of 74 mu M s(1) and 28 mu M s(-1). Despite high OH center dot recombination rates at the plasma exit, the escaping flux is still significant, indicating a viable delivery capability to downstream targets. Its performance with regard to OH center dot generation rates compares well with traditional OH center dot generation techniques such as radiolysis, advanced oxidation processes and enhanced Fenton-chemistry approaches where OH center dot production rates are sub-mu M s(-1). Delivering precisely quantifiable OH(center dot )fluxes provides new opportunities for scientific studies and technological opportunities in cell biology, atmospheric chemistry, protein unfolding and systematic dose studies for plasma-based and other OH center dot related potential medical treatments.