Advances in applications of metabolomics in pluripotent stem cell research
Advances in applications of metabolomics in pluripotent stem cell research
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DOI：
10.1016/j.coche.2016.11.007
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发表时间：
2017-02-01
影响因子：
6.6
通讯作者：
Palecek, Sean P.
中科院分区：
文献类型：
--
作者：
Bhute, Vijesh J.;Bao, Xiaoping;Palecek, Sean P.
干细胞在重编程、增殖和分化过程中经历广泛的代谢重布线，许多研究已经证明代谢在控制干细胞命运中的重要作用。代谢组学的最新应用，研究细胞中小分子的浓度和通量，已经推进了表征和成熟干细胞命运，评估干细胞组织模型中的药物毒性，鉴定生物标志物，以及研究环境对干细胞及其后代代谢途径的影响的努力。展望未来，将代谢组学与其他组学方法相结合，将使人们更深入地了解干细胞复杂的调控机制。
Stem cells undergo extensive metabolic rewiring during reprogramming, proliferation and differentiation, and numerous studies have demonstrated a significant role of metabolism in controlling stem cell fates. Recent applications of metabolomics, the study of concentrations and fluxes of small molecules in cells, have advanced efforts to characterize and maturate stem cell fates, assess drug toxicity in stem cell tissue models, identify biomarkers, and study the effects of environment on metabolic pathways in stem cells and their progeny. Looking to the future, combining metabolomics with other -omics approaches will provide a deeper understanding of the complex regulatory mechanisms of stem cells.