Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: Role of nitric oxide and oxidative stress
Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: Role of nitric oxide and oxidative stress
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DOI：
10.1016/s0735-1097(03)00630-2
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发表时间：
2003-07-16
影响因子：
24
通讯作者：
Yoshizumi, M
中科院分区：
文献类型：
--
作者：
Higashi, Y;Sasaki, S;Yoshizumi, M
目的：本研究的目的是评估身体质量指数（BMI）（包括低BMI）与内皮功能之间的关系。流行病学研究表明，肥胖和低BMI都可能是心血管疾病的危险因素。方法测定87例健康青年男性（BMI低15例，正常51例，肥胖14例，极度肥胖7例）对乙酰胆碱（ACh）和硝酸异山梨酯（ISDN）的前臂血流量（FBF）反应。结果低BMI、肥胖和极度肥胖人群血浆8-羟基-2′-脱氧鸟苷浓度和丙二醛修饰低密度脂蛋白浓度均高于正常人群，低BMI、肥胖和极度肥胖人群血浆8-羟基-2′-脱氧鸟苷浓度和血清丙二醛修饰低密度脂蛋白浓度与正常人群相似。正常组空腹空腹对乙酰胆碱的反应高于其他组（p < 0.001），极度肥胖组空腹空腹对乙酰胆碱的反应低于其他组（p < 0.001）。低BMI组和肥胖组之间的疼痛刺激血管舒张相似。在所有四组中，isdn刺激的血管舒张相似。一氧化氮（no）合成酶抑制剂n - g -单甲基- l-精氨酸输注后，四组之间乙酰胆碱刺激的血管舒张无显著差异。在低BMI、肥胖和极度肥胖组中，维生素C联合输注增强了FBF对乙酰胆碱的反应，而在正常BMI组中则没有。结论：这些发现表明，肥胖和低BMI都可能是内皮依赖性血管舒张受损的危险因素，通过增加氧化应激，导致生物利用度降低(C) 2003（美国心脏病学会基金会）。
OBJECTIVES The purpose of this study was to evaluate the relationship between body mass index (BMI), including low BMIs, and endothelial function.BACKGROUND Epidemiologic study has demonstrated that not only obesity but also a low BMI may be a risk factor for cardiovascular disease.METHODS The forearm blood flow (FBF) response to acetylcholine (ACh) and isosorbide dinitrate (ISDN) was measured in 87 healthy young men (15 low BMI, 51 normal, 14 obese, and 7 extremely obese).RESULTS Plasma concentrations of 8-hydroxy-2'-deoxyguanosine and serum concentrations of malondialdehyde-modified low-density lipoprotein were higher in low BMI, obese, and extremely obese subjects than in normal subjects and were similar among the low BMI, obese, and extremely obese groups. The FBF response to ACh was greater in the normal group than in the other groups (p < 0.001), and was lower in the extremely obese group as compared with the other groups (p < 0.001). The ACh-stimulated vasodilation was similar between the low BMI group and the obese group. The ISDN-stimulated vasodilation was similar in all four groups. There were no significant differences in ACh-stimulated vasodilation between the four groups after the nitric oxide (NO) synthase inhibitor N-G-monomethyl-L-arginine infusion. Co-infusion of vitamin C augmented the FBF response to ACh in low BMI, obese, and extremely obese groups-but not in normal BMI group.CONCLUSIONS These findings suggest that not only obesity but also a low BMI may be a risk factor for impaired endothelium-dependent vasodilation through the increased oxidative stress, leading to the reduced bioavailability of (C) 2003 by the American College of Cardiology Foundation.