Adenosine receptors and fibrosis: a translational review.
Adenosine receptors and fibrosis: a translational review.
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DOI：
10.3410/b3-21
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Cronstein BN
中科院分区：
文献类型：
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作者：
Cronstein BN
腺苷是一种由细胞在直接刺激、缺氧、创伤或代谢应激时释放的腺嘌呤核苷酸在细胞外产生的嘌呤核苷，是一种众所周知的生理和药理学试剂。最近的研究表明，腺苷，作用于其受体，促进伤口愈合，刺激血管生成和基质的生产。随后，还发现腺苷及其受体促进皮肤、肺和肝脏中的纤维化（过量基质产生），但减少心脏纤维化。一种常见的腺苷受体拮抗剂咖啡因可以阻止肝纤维化的发展，这种作用可能解释了流行病学发现，即喝咖啡以剂量依赖性方式降低了因肝脏疾病死亡的可能性。因此，腺苷可能是预防肺、肝和皮肤纤维化的治疗的良好靶点。
Adenosine—a purine nucleoside generated extracellularly from adenine nucleotides released by cells as a result of direct stimulation, hypoxia, trauma, or metabolic stress—is a well-known physiologic and pharmacologic agent. Recent studies demonstrate that adenosine, acting at its receptors, promotes wound healing by stimulating both angiogenesis and matrix production. Subsequently, adenosine and its receptors have also been found to promote fibrosis (excess matrix production) in the skin, lungs, and liver, but to diminish cardiac fibrosis. A commonly ingested adenosine receptor antagonist, caffeine, blocks the development of hepatic fibrosis, an effect that likely explains the epidemiologic finding that coffee drinking, in a dose-dependent fashion, reduces the likelihood of death from liver disease. Accordingly, adenosine may be a good target for therapies that prevent fibrosis of the lungs, liver, and skin.