SPECIATION OF MERCURY IN THE PRIMATE BLOOD AND BRAIN FOLLOWING LONG-TERM EXPOSURE TO METHYL MERCURY
SPECIATION OF MERCURY IN THE PRIMATE BLOOD AND BRAIN FOLLOWING LONG-TERM EXPOSURE TO METHYL MERCURY
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DOI：
10.1006/taap.1994.1026
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发表时间：
1994-02-01
影响因子：
3.8
通讯作者：
BURBACHER, T
中科院分区：
文献类型：
--
作者：
VAHTER, M;MOTTET, NK;BURBACHER, T
测定了雌性食蟹猴血液和脑中的总汞和无机汞含量，这些食蟹猴每日口服甲基汞（MeHg; 50 μg Hg/kg体重）6个月、12个月或18个月，或连续静脉输注氯化汞（200 μg Hg/kg体重）3个月。在正常体重的猴子（体重2.4-4.1公斤）接触甲基汞后，血液中总汞在大约4个月内达到稳定状态（1.1微克汞/克）。血中T12消除时间为26天。I-Hg占总Hg的7%。6个月时，枕极和丘脑中甲基汞的平均浓度约为3 μg Hg/g，12-18个月时为4.5 μg Hg/g。脑内蓄积似乎呈双相性。在12个月暴露结束后，脑中甲基汞的消除T1 - 2为35天。在暴露结束后6-12个月，脑中I-Hg约占T-Hg的9%，18个月为18%，6个月为74%。丘脑的I-Hg浓度略高于枕极。消除T1 2碘汞是非常长的，在几年的顺序。最有可能的是，I-Hg是由脑中甲基汞的去甲基化形成的。在接触HgCl 2的猴子中，血液中的I-Hg浓度为0.6 μg/g时，脑中的I-Hg浓度仅为0.1 μg/g。三只体重较重的猴子（体重5.0-6.1公斤）接触甲基汞后，血液中的汞含量增加到约2微克/克，表明甲基汞在脂肪中的分布有限。由于血液中汞含量高，再加上脑-血分布比率高，脑中汞浓度（7-22微克汞/克）比正常体重的猴子高得多。
Total (I-Hg) and inorganic (I-Hg) mercury in blood and brain of female Macaca fascicularis monkeys, exposed to daily peroral doses of methyl mercury (MeHg; 50 μg Hg/kg body wt) for 6, 12, or 18 months, or to continuous iv infusion of HgCI2 (200 μg Hg/kg body wt) for 3 months, were determined. In normal weight monkeys (2.4-4.1 kg body wt) exposed to MeHg, steady state of T-Hg in blood (1.1 μg Hg/g) was reached in about 4 months. The elimination T1 2 in blood was 26 days. I-Hg constituted 7% of T-Hg in blood. The average concentration of MeHg in occipital pole and thalamus was about 3 μg Hg/g at 6 months and 4.5 μg Hg/g at 12-18 months. Accumulation in brain seemed to be biphasic. Following termination of 12 months exposure, elimination T1 2 for MeHg in brain was 35 days. I-Hg constituted about 9% of T-Hg in brain at 6-12 months, 18% at 18 months, and 74% at 6 months after termination of exposure. The I-Hg concentrations were somewhat higher in thalamus than in occipital pole. The elimination T1 2 for I-Hg was extremely long, on the order of years. Most likely, the I-Hg was formed by demethylation of MeHg in the brain. In monkeys exposed to HgCl2, blood levels of 0.6 μg I-Hg/g gave rise to brain I-Hg levels of about 0.1 μg/g only. In three heavy weight monkeys (5.0-6.1 kg body wt) exposed to MeHg, blood Hg increased to about 2 μg Hg/g, indicating a limited distribution of MeHg to fat. The Hg concentrations in brain (7-22 μg Hg/g) were considerably higher than those in normal weight monkeys, due to the high blood Hg levels in combination with a high brain-to-blood distribution ratio.