A DESCRIPTION OF SPERMIOGENESIS IN THE MOUSE AND ITS USE IN ANALYSIS OF THE CYCLE OF THE SEMINIFEROUS EPITHELIUM AND GERM CELL RENEWAL
A DESCRIPTION OF SPERMIOGENESIS IN THE MOUSE AND ITS USE IN ANALYSIS OF THE CYCLE OF THE SEMINIFEROUS EPITHELIUM AND GERM CELL RENEWAL
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DOI：
10.1002/aja.1000990303
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发表时间：
1956-01-01
影响因子：
--
通讯作者：
OAKBERG, EF
中科院分区：
文献类型：
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作者：
OAKBERG, EF
描述了正常成年小鼠精子发生的16个阶段。精子细胞发育的前12个阶段是确定生精上皮细胞周期中连续步骤的基础。结合细胞计数和小管分类，确定精原细胞的发育顺序。精原细胞分为A型、中间型和B型。A型细胞通过一系列的三次分裂进行繁殖;在第三次分裂后，大多数细胞核转化为中间型精原细胞。中间型精原细胞分裂形成B型细胞，B型细胞又分裂形成静止的初级精母细胞。少数A型精原细胞未能转化为中间型，从小管阶段III-VIII开始保持有丝分裂不活跃，然后在阶段IX分裂，开始新的精原细胞增殖周期。坏死被认为是一个重要因素，在减少精原细胞的频率低于预期的基础上，休眠的A型细胞在第八阶段的三个分裂。同样，减数分裂过程中的细胞死亡导致精子细胞减少到初级精母细胞计数预测值的87%。
Sixteen stages of spermiogenesis are described for normal adult mouse. The first 12 stages of spermatid development form the basis for identification of successive steps in the cycle of the seminiferous epithelium. By combination of this classification of tubules with cell counts, developmental sequences of spermatogonia were determined. Spermatogonia of A, intermediate, and B types were identified. Type A cells multiply by a series of three divisions; after the third division most nuclei transform into spermatogonia of the intermediate type. Intermediate spermatogonia divide to form type B cells, which in turn divide to form resting primary spermatocytes. A few type A spermatogonia fail to transform into the intermediate type, remain mitotically inactive from tubule stage III-VIII, then divide at stage IX to initiate a new cycle of spermatogonial multiplication. Necrosis is considered an important factor in reduction of spermatogonia to a frequency less than would be expected on the basis of three divisions of the dormant type A cells at stage VIII. Likewise, cell death during meiotic division results in decrease of spermatids to 87% of the value predicted on the basis of primary spermatocyte counts.