A novel family of structurally stable double stranded DNA catenanes
A novel family of structurally stable double stranded DNA catenanes
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DOI：
10.1039/c4cc02030h
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Famulok, Michael
中科院分区：
文献类型：
--
作者：
Lohmann, Finn;Valero, Julian;Famulok, Michael
在这里，我们描述了不同的结构稳定和高度多价的DNA链环的设计、组装和表征。我们合成了一系列不同的链状DNA纳米结构，其中对称的含两个126或168碱基对的环，非对称的含126和168个碱基对的环，以及[3]连环的含三个126碱基对的环。环的迁移率的可逆和定量的开/关开关被证明是将这些链环用作动态DNA纳米结构的概念验证。
Here we describe the design, assembly and characterisation of different structurally stable and highly polyvalent DNA catenanes. We synthesized a series of different catenated DNA nanostructures, among them symmetric ones containing two 126 or 168 base-pair rings, non-symmetric ones with a 126 and a 168 base-pair ring, and a [3]catenane containing three 126 base-pair rings. Reversible and quantitative on/off switching of the mobility of the rings was demonstrated as a proof-of-concept for the employment of these catenanes as dynamic DNA-nanostructures.