Relationship between Virus-Neutralizing Antibody Levels and the Number of Rabies Vaccinations: a Prospective Study of Dogs in Japan
Relationship between Virus-Neutralizing Antibody Levels and the Number of Rabies Vaccinations: a Prospective Study of Dogs in Japan
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DOI：
10.7883/yoken.66.17
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发表时间：
2013-01-01
影响因子：
2.2
通讯作者：
Nishizono, Akira
中科院分区：
文献类型：
--
作者：
Watanabe, Ippei;Yamada, Kentaro;Nishizono, Akira
在过去的60年里，日本每年都对狗进行大规模的狂犬病疫苗接种。为了评估犬的狂犬病毒中和抗体（VNA）水平和当前疫苗接种程序的基本原理，我们使用快速荧光焦点抑制试验来确定日本动物医院756只狗的VNA水平。我们发现51.1%接受1次狂犬病疫苗接种的狗具有保护性VNA水平（>= 0.5 IU/ml），几何平均值为0.61 IU/ml。相比之下，97.8%接种过至少两次疫苗的狗具有保护性VNA水平，几何平均值为7.86 IU/ml。此外，97.9-100%至少接种两次疫苗的狗在最后一次接种疫苗后的第二年仍保持保护性VNA水平。尽管至少接种两次疫苗的狗的VNA水平在最后一次接种疫苗2年后趋于下降，但78.9%的狗仍保持保护性VNA水平。因此，目前的狂犬病疫苗接种计划提供了足够的保护，但需要改进登记制度和疫苗接种计划，以确保更多的狗接种狂犬病疫苗。
A mass rabies vaccination of dogs has been conducted annually in Japan over the last 60 years. To assess both current levels of rabies virus-neutralizing antibody (VNA) in dogs and the rationale for current vaccination procedures, we used a rapid fluorescent focus inhibition test to determine VNA levels in 756 dogs that had visited animal hospitals in Japan. We found that 51.1% of the dogs that had received 1 rabies vaccination had protective VNA levels (>= 0.5 IU/ml) with a geometric mean of 0.61 IU/ml. In contrast, 97.8% of the dogs that had been vaccinated at least twice had protective VNA levels with a geometric mean of 7.86 IU/ml. Furthermore, 97.9-100% of the dogs vaccinated at least twice retained protective VNA levels into the second year after the last vaccination. Although VNA levels in the dogs vaccinated at least twice tended to decline 2 years after the last vaccination, 78.9% retained protective VNA levels. Thus, the current rabies vaccination schedule provides adequate protection, but the registration system and vaccination schedule needs to be improved to ensure that increased numbers of dogs are vaccinated against rabies.