Pediatric nonalcoholic steatohepatitis associated with hypopituitarism
Pediatric nonalcoholic steatohepatitis associated with hypopituitarism
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DOI：
10.1007/s00535-004-1541-4
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发表时间：
2005-03-01
影响因子：
6.3
通讯作者：
Takano, K
中科院分区：
文献类型：
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作者：
Nakajima, K;Hashimoto, E;Takano, K
我们经历了两例儿童非酒精性脂肪性肝炎（NASH）与垂体功能减退症。第一个病人在5岁时被诊断为颅咽管瘤。在手术治疗后，患者逐渐变得肥胖，并观察到转氨酶升高。16岁时，患者被诊断为NASH伴肝硬化。他开始接受激素替代治疗;然而，通过透明质酸和血小板计数评估，他的胰岛素抵抗和肝纤维化进展。此外，他的高瘦素血症持续存在。第二名患者在10岁时被诊断为由于胎儿窒息导致垂体功能障碍，并开始接受激素替代治疗。该患者一生中一直肥胖。他在1.8岁时被诊断为NASH伴晚期纤维化。重要的是肝病学家和内分泌学家要意识到垂体功能障碍和NASH之间的关联。
We experienced two cases of pediatric nonalcoholic steatohepatitis (NASH) associated with hypopituitarism. The first patient was diagnosed with a craniopharyngioma at 5 years of age. After an operation to treat the condition, the patient gradually became obese, and an elevation of transaminases was observed. At 16 years of age, the patient was diagnosed as having NASH with liver cirrhosis. He was started on hormone replacement therapy; however, his insulin resistance and liver fibrosis, as evaluated by hyaluronic acid and platelet count, progressed. In addition, his hyperleptinemia continued. The second patient was diagnosed, at 10 years of age, as having pituitary dysfunction due to fetal asphyxia, and he was started on hormone replacement therapy. This patient was noted to have been obese throughout his life. He was diagnosed as having NASH with advanced fibrosis at 1.8 years of age. It is important for both hepatologists and endocrinologists to be aware of the association between pituitary dysfunction and NASH.