Thyroid function is associated with carotid intima-media thickness in euthyroid subjects.
Thyroid function is associated with carotid intima-media thickness in euthyroid subjects.
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DOI：
10.1016/j.atherosclerosis.2008.09.022
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发表时间：
2009-06-01
期刊：
影响因子：
5.3
通讯作者：
Aoyagi, Kiyoshi
中科院分区：
文献类型：
--
作者：
Takamura, Noboru;Akilzhanova, Ainur;Aoyagi, Kiyoshi
为了研究甲状腺功能与颈动脉内膜中层厚度（CIMT）之间的关系，在一个相对较大的甲状腺功能正常的一般人群中，我们最初招募了1772名日本成年人（421名男性和1351名女性），他们参加了40岁以上的一般人群的医学筛查项目。为了仅评估甲状腺功能正常的受试者，没有血管疾病和/或其主要危险因素，排除了1129名受试者，纳入了643名受试者（175名男性和468名女性）进行进一步分析。进行简单和多元线性回归分析，以评估游离甲状腺素（fT 4）和促甲状腺激素（TSH）水平和其他现有参数，包括颈动脉内膜中层厚度。通过调整年龄和性别的多元线性回归分析，游离甲状腺素与甘油三酯（β =0.07，p=0.015）、颈动脉内膜中层厚度（β =-0.091，p=0.049）和促甲状腺激素（β =-0.091，p =0.003）显着相关。促甲状腺激素与高密度脂蛋白胆固醇（HDL-C）（β =-0.001，p=0.015）、HbA（1c）（β =0.038，p=0.045）、颈动脉内膜中层厚度（β =0.27，p=0.001）和游离甲状腺素（β =-0.15，p=0.003）显著相关。校正混杂因素后，游离甲状腺素仅与颈动脉内膜中层厚度显著相关（β =-0.13，p=0.043），促甲状腺激素与HDL-C显著相关（β =-0.001，p
To investigate the relationship between thyroid function and carotid intima-media thickness (CIMT) in a relatively large general population with euthyroid status we initially enrolled 1772 Japanese adults (421 men and 1351 women) who participated in a medical screening program for the general population over 40 years old. To evaluate only euthyroid subjects without vascular diseases and/or its major risk factors, 1129 were excluded and 643 participants (175 men and 468 women) were included for further analysis. Simple and multivariate linear regression analyses were performed to evaluate free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels and other existing parameters, including carotid intima-media thickness. By multivariate linear regression analysis adjusted for age and sex, free thyroxine was significantly correlated with triglycerides (beta=0.07, p=0.015), carotid intima-media thickness (beta=-0.091, p=0.049), and thyroid-stimulating hormone (beta=-0.091, p=0.003). Thyroid-stimulating hormone was significantly correlated with high-density lipoprotein cholesterol (HDL-C) (beta=-0.001, p=0.015), HbA(1c) (beta=0.038, p=0.045), carotid intima-media thickness (beta=0.27, p=0.001), and free thyroxine (beta=-0.15, p=0.003). When adjusted for confounding factors, free thyroxine was significantly correlated only with carotid intima-media thickness (beta=-0.13, p=0.043) and thyroid-stimulating hormone was significantly correlated with HDL-C (beta=-0.001, p