New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations
New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations
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DOI：
10.1073/pnas.0307101101
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发表时间：
2004-04-13
影响因子：
11.1
通讯作者：
Ojima, I
中科院分区：
文献类型：
--
作者：
Hua, ZH;Vassar, VC;Ojima, I
基于具有轴向手性的对映体纯6，6 '-二甲基联苯酚，开发了单齿亚磷酰胺配体。这些手性配体易于制备并且对于修饰是灵活的。这些配体的微调能力在烯丙基氰的不对称氢化反应和二乙基锌与环烯酮的共轭加成反应中实现高的对映选择性中起着重要作用。
Monodentate phosphoramidite ligands have been developed based on enantiopure 6,6'-dimethylbiphenols with axial chirality. These chiral ligands are easy to prepare and flexible for modifications. The fine-tuning capability of these ligands plays a significant role in achieving high enantioselectivity in the asymmetric hydro-formylation of allyl cyanide and the conjugate addition of diethylzinc to cycloalkenones.