Tendon matrix composition and turnover in relation to functional requirements
Tendon matrix composition and turnover in relation to functional requirements
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DOI：
10.1111/j.1365-2613.2007.00552.x
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发表时间：
2007-08-07
影响因子：
3
通讯作者：
Birch, Helen L.
中科院分区：
文献类型：
--
作者：
Birch, Helen L.
肌腱是致密的规则结缔组织结构，其根据其连接肌肉和骨骼的解剖位置来定义。尽管有这些明显的共同特征，但体内不同部位的肌腱在其形态、分子和机械特性方面表现出显着的差异，这些特性与其专门功能有关。了解这些差异对于了解健康和疾病中肌腱生物学的各个方面是必要的。在我们的工作中，我们使用了一个组合的机械评估，组织学测量和分子分析的矩阵在功能不同的肌腱，以确定功能和结构之间的关系。我们已经发现，在运动过程中受到高应变的弹簧状肌腱和受到低得多的应变的位置肌腱之间的材料和分子特性的显着差异。此外，我们有数据表明，不仅是基质成分不同，而且细胞合成和降解基质（基质周转）的能力也因肌腱类型而异。我们认为，这些差异与肌腱在生活中的正常活动中经历的应变大小有关。肌腱细胞可能在胚胎发育过程中预先编程，以适应它们在生活中遇到的应变，或者可能只是对它们所处的特定应变环境做出反应。阐明导致肌腱细胞特化的控制机制将对基于细胞的治疗和修复受损肌腱的工程策略产生重要影响。
Tendons are dense regular connective tissue structures that are defined based on their anatomical position of connecting muscle to bone. Despite these obvious commons features tendons from different locations within the body show remarkable variation in terms of their morphological, molecular and mechanical properties which relates to their specialized function. An appreciation of these differences is necessary to understand all aspects of tendon biology in health and disease. In our work, we have used a combination of mechanical assessment, histological measurements and molecular analysis of matrix in functionally distinct tendons to determine relationships between function and structure. We have found significant differences in material and molecular properties between spring-like tendons that are subjected to high strains during locomotion and positional tendons which are subjected to much lower strains. Furthermore, we have data to suggest that not only is the matrix composition different but also the ability of cells to synthesize and degrade the matrix (matrix turnover) varies between tendon types. We propose that these differences relate to the magnitude of strain that the tendon experiences during normal activities in life. Tendon cells may be preprogrammed during embryological development for the strain they will encounter in life or may simply respond to the particular strain environment they are subjected to. The elucidation of controlling mechanisms resulting in tendon cell specialization will have important consequences for cell based therapies and engineering strategies to repair damaged tendons.