Guillain-Barre Syndrome Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Detection and Coronavirus Disease 2019 in a Child
Guillain-Barre Syndrome Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Detection and Coronavirus Disease 2019 in a Child
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DOI：
10.1093/jpids/piaa086
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发表时间：
2020-09-01
影响因子：
3.2
通讯作者：
Rasker, Johannes J.
中科院分区：
文献类型：
--
作者：
Khalifa, Maher;Zakaria, Fairouz;Rasker, Johannes J.
冠状病毒病（COVID-19）是由严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）感染引起的。中国的医生报告了据信是第一例与急性格林-巴利综合征（GBS）相关的SARS-CoV-2成人感染病例，随后是5例意大利成人患者和另一例美国患者。在目前的报告中，我们提出了一个儿童GBS和SARS-CoV-2感染的关联的第一个描述之一。在我们的设施，一个11岁的男孩提出了典型的特点，GBS和5天后，麻疹样皮疹的双手手掌。在神经系统症状开始前三周，该男孩经历了一次轻度发热性疾病发作，伴有轻度呼吸道表现和持续咳嗽。经口咽拭子逆转录聚合酶链反应检测确诊为SARS冠状病毒2型感染。我们的病人的病程强烈提示GBS的发展和SARS-CoV-2感染之间可能存在关系。鉴于先前关于GBS与COVID-19相关的病例报告，对该病例进行了讨论。
Coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported what is believed to be the first adult case of a SARS-CoV-2 infection associated with acute Guillain-Barre syndrome (GBS), followed by 5 adult Italian patients and another case in the United States. In the current report, we present one of the first descriptions of an association of GBS and SARS-CoV-2 infection in a child. In our facility, an 11-year-old boy presented with typical features of GBS and, after 5 days, a morbilliform skin rash over the palms of both hands. Three weeks before the start of the neurological symptoms, the boy had experienced an episode of mild febrile illness with mild respiratory manifestations and a persistent cough. The diagnosis of SARS-CoV-2 infection was confirmed by oropharyngeal swab on reverse-transcription polymerase chain reaction assay. The disease course of our patient strongly suggests a possible relationship between the development of GBS and SARS-CoV-2 infection. The case is discussed in view of previous case reports regarding the association of GBS and COVID-19.