Atypical E2F Transcriptional Repressor DEL1 Acts at the Intersection of Plant Growth and Immunity by Controlling the Hormone Salicylic Acid
Atypical E2F Transcriptional Repressor DEL1 Acts at the Intersection of Plant Growth and Immunity by Controlling the Hormone Salicylic Acid
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DOI：
10.1016/j.chom.2014.03.007
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发表时间：
2014-04-09
影响因子：
30.3
通讯作者：
Wildermuth, Mary C.
中科院分区：
文献类型：
--
作者：
Chandran, Divya;Rickert, Joshua;Wildermuth, Mary C.
在植物中，免疫的激活往往与生长成反比。在病原菌挑战和免疫的背景下控制植物生长的机制尚不清楚。研究了拟南芥对白粉菌的侵染，我们发现拟南芥非典型的E2F DEL1，一个已知促进细胞增殖的转录抑制因子，抑制了激素水杨酸(SA)的积累，水杨酸(SA)是植物免疫的既定调节因子。DEL1基因缺失的植株对病原菌的抵抗力更强，而且比野生型略小。DEL1基因缺失植株的抗性和大小表型是由于在没有病原菌攻击的情况下SA的诱导和免疫的激活。此外，增强的疾病易感性5(EDS5)是提高SA和免疫力所需的SA转运蛋白，是DEL1直接抑制的靶标。综上所述，这些发现表明DEL1对SA水平的控制有助于调节发育中的叶片生长和免疫之间的平衡。
In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves.