Opsonization of Actinobacillus actinomycetemcomitans by immunoglobulin G antibody reactive with phosphorylcholine.
Opsonization of Actinobacillus actinomycetemcomitans by immunoglobulin G antibody reactive with phosphorylcholine.
复制标题
与磷酸胆碱反应的免疫球蛋白 G 抗体对放线放线杆菌的调理作用。
DOI：
10.1128/iai.70.11.6485-6488.2002
复制
发表时间：
2002
影响因子：
3.1
通讯作者：
Schenkein,HarveyA
中科院分区：
文献类型：
--
作者：
Purkall,Donald;Tew,JohnG;Schenkein,HarveyA
We used two strains ofActinobacillus actinomycetemcomitans, one bearing phosphorylcholine (PC) (strain D045D-40) and one devoid of PC antigens (strain DB03A-42), as well as a nonencapsulated strain ofStreptococcus pneumoniae(strain 39937), to examine the opsonic properties of physiological concentrations (⩽30 μg/ml) of purified human anti-PC immunoglobulin G (IgG). Anti-PC bound to bothA. actinomycetemcomitansDO45D-40 andS. pneumoniae39937 and induced superoxide anion production by polymorphonuclear neutrophils; induction of the oxidative burst was inhibited by antibodies to either CD16 or CD32. Thus, anti-PC IgG at concentrations present in most human sera promotes the opsonization of PC-expressing strains ofA. actinomycetemcomitansin the absence of complement, implying that anti-PC may be a protective antibody against such strains of bacteria.
