Transcription activation in bacteria: ancient and modern
Transcription activation in bacteria: ancient and modern
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DOI：
10.1099/mic.0.000783
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发表时间：
2019-04-01
期刊：
影响因子：
2.8
通讯作者：
Busby, Stephen J. W.
中科院分区：
文献类型：
--
作者：
Busby, Stephen J. W.
基因转录的激活对细菌的许多适应和分化过程至关重要。在这里，我回顾了转录因子可以激活细菌启动子上特定转录物的分子机制。这个故事是在Marjory Stephenson在细菌酶适应方面的开创性工作的背景下提出的，并在转录调节机制如何进化的更大背景下设置了不同的机制。
Activation of the transcription of genes is central to many processes of adaptation and differentiation in bacteria. Here, I review the molecular mechanisms by which transcription factors can activate the initiation of specific transcripts at bacterial promoters. The story is presented in the context of Marjory Stephenson's pioneering work on enzymatic adaptation in bacteria, and sets the different mechanisms in the greater context of how transcription regulatory mechanisms evolved.