Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells.
Toxic variability and radiation sensitization by dichlorodiammineplatinum(II) complexes in Salmonella typhimurium cells.
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二氯二氨铂 (II) 复合物在鼠伤寒沙门氏菌细胞中的毒性变异和辐射致敏作用。
DOI：
10.2307/3576334
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发表时间：
1984
影响因子：
3.4
通讯作者：
R. Richmond
中科院分区：
文献类型：
--
作者：
R. Richmond
The oxidative coordination compound cis-dichlorodiammineplatinum(II) (cis-DDP) is again shown to be a hypoxic cell radiation sensitizer. The mechanism of cis-DDP-induced radiation sensitization is complex. Results here indicate that cis-DDP sensitization operates in part through reactive free radicals, in part through the interactions of radiation-induced reactive Pt(I) intermediates, and in part through the involvement of thermodynamic and kinetic aspects of Pt(II)-DNA binding during irradiation. For the first time, radiation sensitization by trans-DDP is compared with a sensitizing concentration of cis-DDP within the same study. Both analogs are sensitizers, but with significant differences. Further, irradiated hypoxic solutions of cis-DDP are found to be more toxic than unirradiated solutions.
使用核酸外切酶 III 确定 DNA 确定序列中稳定损伤的位点：环丁烷嘧啶二聚体以及顺式和反式二氯二氨铂 II 示例。
影响因子：
14.9
作者：
Royer-Pokora,B;Gordon,LK;Haseltine,WA
通讯作者：
Haseltine,WA