Shared susceptibility for celiac disease and inflammatory bowel disease?
Shared susceptibility for celiac disease and inflammatory bowel disease?
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乳糜泻和炎症性肠病有共同的易感性吗？
DOI：
10.1080/00365520802158630
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发表时间：
2008
影响因子：
1.9
通讯作者：
Landgren,Ola
中科院分区：
文献类型：
--
作者：
Gao,Ying;Linet,MarthaS;Gridley,Gloria;Mellemkjaer,Lene;Hemminki,Kari;Goldin,LynnR;Landgren,Ola
致编辑：我们饶有兴趣地阅读了利兹等人的研究报告。评估乳糜泻与炎症性肠病的关系[1]。在他们的调查中，他们发现炎症性肠病在乳糜泻患者中的患病率增加。有趣的是，最近的一份报告表明，乳糜泻和溃疡性结肠炎可能具有共同的遗传风险因素，包括紧密连接介导的肠道屏障缺陷[2]。受这些事实的启发，我们试图进行一项以斯堪的纳维亚人群为基础的大型研究，以调查是否有证据表明乳糜泻、炎症性肠病和其他自身免疫性疾病共同发生。我们利用了一个现有的基于斯堪的纳维亚人口的大型数据库，这个数据库已经在前面描述过了[3×5]。简而言之，该数据库包括瑞典(1958×98)和丹麦(1968×97)确诊的所有淋巴瘤患者(N041,179)、以人群为基础的对照93781人，以及他们所有可联系的一级血亲(N0371,043)[3×5]。因此，数据库共收录了506,003人。通过与瑞典和丹麦全国住院患者登记的记录链接，我们收集了有关乳糜泻和其他32种自身免疫性疾病及相关疾病的出院记录数据[4]。对于淋巴瘤患者，我们将有关乳糜泻和其他自身免疫性疾病的信息限制在淋巴瘤诊断日期前一年。我们使用x2统计来确定乳糜泻患者是否过度合并炎症性肠病和其他自身免疫性疾病。在我们的研究中，我们能够证实和推广Leeds等人的结果[1]。首先，我们定义了总共253名被诊断为乳糜泻的出院患者(患病率为每2000人1人)。其次，当评估乳糜泻和其他自身免疫性疾病的共存时，我们发现有(与没有)乳糜泻的人有更高的溃疡性结肠炎的频率(N08，pB0。0001)和克隆氏病(N06，pB0.0001)。此外，基于较小的数字，我们发现其他自身免疫性疾病的共同发生(表I)。
TO THE EDITOR: We read with interest the study by Leeds et al. assessing the relationship between celiac disease and inflammatory bowel disease [1]. In their investigation, they found an increased prevalence of inflammatory bowel disease among celiac disease patients. Interestingly, in a recent report it is suggested that celiac disease and ulcerative colitis might share common genetic risk factors involving tight junction-mediated barrier defects of the bowel [2]. Inspired by these facts, we sought to conduct a large Scandinavian population-based study to investigate whether there is evidence for co-occurrence of celiac disease, inflammatory bowel disease, and other autoimmune disorders. We took advantage of an existing large Scandinavian population-based database which has been described previously [3Á5]. Briefly, the database includes all lymphoma patients (n041, 179) diagnosed in Sweden (1958Á98) and Denmark (1968Á 97), 93,781 population-based controls, and all their linkable 1st-degree blood relatives (n0371, 043)[3Á 5]. Thus, a total of 506,003 individuals were included in the database. Through record-linkage with the nation-wide inpatient registers in Sweden and Denmark, we captured hospital-discharge record data on celiac disease and a wide range of 32 other autoimmune and related disorders [4]. For lymphoma patients, we restricted the information on celiac disease and other autoimmune disorders to one year prior to the date of lymphoma diagnosis. We used x2 statistics to determine whether patients with celiac disease had excess co-occurrence of inflammatory bowel disease and other autoimmune disorders.In our study, we were able to confirm and extend the results by Leeds et al.[1]. First, we defined a total of 253 individuals (prevalence rate Â1 per 2000) with a hospital-discharge diagnosis of celiac disease. Second, when evaluating the co-occurrence of celiac disease and other autoimmune disorders, we found persons with (versus without) celiac disease to have a higher frequency of ulcerative colitis (n08, pB0. 0001) as well as Crohn’s disease (n06, pB0. 0001). Also, based on small numbers, we found co-occurrence for other autoimmune conditions (Table I).