Dopamine receptors: general aspects
Dopamine receptors: general aspects
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DOI：
10.1016/s0035-3787(04)71067-x
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发表时间：
2004-09-01
影响因子：
3
通讯作者：
Bordet, R
中科院分区：
文献类型：
--
作者：
Bordet, R
特异性蛋白g偶联受体介导多巴胺在其投射区的作用。5种多巴胺能受体已被克隆、鉴定并分为两个家族，D1样家族（D1-和d5受体亚型）和D2样家族（D2， D3-和d4受体亚型）。这五种多巴胺受体亚型在转导、分布、药理学、功能和调节方面具有多样性，导致多巴胺能系统失调导致神经精神疾病的多效性病理生理和药理学参与。
Specific protein G-coupled receptors mediate the effects of dopamine in its projection areas. Five dopaminergic receptors have been cloned, characterized and classified in two families, the D1-like family (D1- and D5-receptor subtypes) and the D2-like family (D2, D3- and D4-receptor subtypes). These five dopamine receptor subtypes are characterized by their diversity in terms of transduction, distribution, pharmacology, functions, and regulation, leading to pleiotropic pathophysiological and pharmacological involvements in neuropsychiatric disorders underlain by a deregulation of the dopaminergic system.