Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light.
Rapid, Reversible Release from Thermosensitive Liposomes Triggered by Near-Infra-Red Light.
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DOI：
10.1002/ppsc.201400035
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Zasadzinski JA
中科院分区：
文献类型：
--
作者：
Forbes N;Pallaoro A;Reich NO;Zasadzinski JA
我们提出了一种新的药物载体，由等离子体中空金纳米壳(HGN)化学连接到用溶固体脂(LTSL)制成的温度敏感的脂质体(LTSL)组成。用生理友好的近红外光在800 nm的激光强度下连续照射2.5分钟，激光强度比已知的损伤皮肤的强度低一个数量级，产生局部加热到脂膜。加热以一种辐射剂量依赖的但可逆的方式增加脂质体的渗透性，导致小分子如自猝灭染料羧基荧光素或化疗药物阿霉素的快速释放，而不会提高本体温度。通过比较LTSL通过本体加热和辐照引起的染料释放速率，推测了激光照射下纳米壳层温度的局部升高。LTSL的激光照射能够精确控制内容物的释放，并将低温度梯度限制在激光焦点照射的区域。快速局部释放和局部加温的联合作用提供了协同效应，与相同浓度的游离阿霉素相比，具有雄激素抗性的PPC-1前列腺癌细胞毒性几乎翻了一番。
We present a novel drug carrier consisting of plasmonic hollow gold nanoshells (HGN) chemically tethered to liposomes made temperature sensitive with lysolipids (LTSL). Continuous-wave irradiation by physiologically friendly near infra-red light at 800 nm for 2.5 minutes at laser intensities an order of magnitude below that known to damage skin generates heating localized to the liposome membrane. The heating increases the liposome permeability in an irradiation dose-dependent, but reversible manner, resulting in rapid release of small molecules such as the self-quenching dye carboxyfluorescein or the chemotherapeutic doxorubicin, without raising the bulk temperature. The local rise in nanoshell temperature under laser irradiation was inferred by comparing dye release rates from the LTSL via bulk heating to that induced by irradiation. Laser-irradiation of LTSL enables precise control of contents release with low temperature gradients confined to areas irradiated by the laser focus. The combined effects of rapid local release and localized hyperthermia provide a synergistic effect as shown by a near doubling of androgen resistant PPC-1 prostate cancer cell toxicity compared to the same concentration of free doxorubicin.
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影响因子：
4.4
作者：
Anyarambhatla, GR;Needham, D
通讯作者：
Needham, D
影响因子：
17.1
作者：
Baffou, Guillaume;Quidant, Romain;Javier Garcia de Abajo, F.
通讯作者：
Javier Garcia de Abajo, F.
DOI：
10.1073/pnas.041420998
发表时间：
2001-02-13
影响因子：
11.1
作者：
Jung, HT;Coldren, B;Kaler, EW
通讯作者：
Kaler, EW
影响因子：
11.2
作者：
Manzoor AA;Lindner LH;Landon CD;Park JY;Simnick AJ;Dreher MR;Das S;Hanna G;Park W;Chilkoti A;Koning GA;ten Hagen TL;Needham D;Dewhirst MW
通讯作者：
Dewhirst MW
影响因子：
51.1
作者：
Issels, Rolf D.;Lindner, Lars H.;Verweij, Jaap;Wust, Peter;Reichardt, Peter;Schem, Baard-Christian;Abdel-Rahman, Sultan;Daugaard, Soeren;Salat, Christoph;Wendtner, Clemens-Martin;Vujaskovic, Zeljko;Wessalowski, Ruediger;Jauch, Karl-Walter;Duerr, Hans Roland;Ploner, Ferdinand;Baur-Melnyk, Andrea;Mansmann, Ulrich;Hiddemann, Wolfgang;Blay, Jean-Yves;Hohenberger, Peter
通讯作者：
Hohenberger, Peter