Trajectory and Predictors of Depression and Anxiety Disorders in Mothers With the FMR1 Premutation.
Trajectory and Predictors of Depression and Anxiety Disorders in Mothers With the FMR1 Premutation.
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DOI：
10.1016/j.biopsych.2015.07.015
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发表时间：
2016-05-15
影响因子：
10.6
通讯作者：
Bailey DB Jr
中科院分区：
文献类型：
--
作者：
Roberts JE;Tonnsen BL;McCary LM;Ford AL;Golden RN;Bailey DB Jr
Although the FMR1 premutation is associated with elevated prevalence of psychiatric disorders, the longitudinal course of symptoms has not been established. The present study followed a sample of women with the FMR1 premutation to characterize the incidence, stability and predictors of mood and anxiety disorders across a 3-year period. Participants included 83 women with the FMR1 premutation (mean age=38.35) who completed the Structured Clinical Interview for the DSM-IV-I at two time points, three years apart. Additional information was obtained regarding demographic, child, and biomedical (e.g. medication, menopause, CGG repeats) factors. We found increased prevalence of major depressive disorder (MDD) and anxiety disorders over time, with adverse outcomes predicted by complex interactions among biological, behavioral and environmental risk factors. Lifetime MDD increased from 46% to 54% and lifetime anxiety disorders from 28% to 35%. Mid-range CGG repeats, elevated child problem behavior and divorced marital status conveyed elevated risk for psychiatric diagnoses. Primary ovarian insufficiency was highly prevalent (41%) but did not account for elevated rates of psychiatric diagnoses. Medication use was highly reported (41%), particularly in women with MDD or anxiety, with selective serotonin reuptake inhibitors reported as the most commonly used medication across diagnostic groups. The elevated prevalence of depression and anxiety in women with the FMR1 premutation is a clear and pressing concern given the frequent occurrence of the FMR1 premutation in the general community and the adverse outcomes – at both an individual and systems levels – associated with psychiatric disorders in this population.
