Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells
Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells
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DOI：
10.1002/2211-5463.12880
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发表时间：
2020-05-30
期刊：
影响因子：
2.6
通讯作者：
Li, Qing
中科院分区：
文献类型：
--
作者：
Lin, Shu-Li;Wang, Mei;Li, Qing
尽管在预防和治疗方面有所改进，但宫颈癌（CC）仍然对妇女健康构成严重威胁。CHMP 4C（染色质修饰蛋白4C）是转运所需的内体分选复合物的一个亚基，在细胞核和细胞质中表达。在此，我们研究了CHMP 4C对CC细胞生物学行为的影响及其机制。我们报告称，CC组织中CHMP 4C表达较高，且CHMP 4C高表达与较低的生存率相关。C-33 A细胞中CHMP 4C的上调促进细胞增殖、迁移和侵袭，而Ca Ski细胞中CHMP 4C的下调具有相反的作用。此外，CHMP 4C的过度表达诱导上皮-间充质转化途径的活化，而CHMP 4C的耗竭抑制活化。我们的研究结果表明，CHMP 4C通过调节上皮-间充质转化促进CC细胞的活力和运动性，并可能有助于CC治疗的新生物标志物的鉴定。
Despite improvements in prevention and treatment, cervical cancer (CC) still poses a serious threat to women's health. CHMP4C (chromatin modified protein 4C) is a subunit of the endosomal sorting complex required for transport, which is expressed in both nucleus and cytoplasm. Here, we examined the effect of CHMP4C on the biological behavior of CC cells and the underlying mechanisms. We report that CHMP4C expression is higher in CC tissues, and high CHMP4C expression is associated with lower survival. Up-regulation of CHMP4C in C-33A cells accelerates cell proliferation, migration and invasion, whereas down-regulation of CHMP4C in Ca Ski cells had the opposite effect. Moreover, overexpression of CHMP4C induced activation of the epithelial-mesenchymal transition pathway, whereas depletion of CHMP4C inhibited activation. Our results suggest that CHMP4C contributes to the viability and motility of CC cells by modulating epithelial-mesenchymal transition and may facilitate the identification of novel biomarkers for CC therapy.