Evaluation of bladder microvasculature with high-resolution photoacoustic imaging.
Evaluation of bladder microvasculature with high-resolution photoacoustic imaging.
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DOI：
10.1364/ol.36.004815
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发表时间：
2011-12-15
期刊：
影响因子：
3.6
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Xie Z;Roberts W;Carson P;Liu X;Tao C;Wang X
我们探讨了一种新兴的基于激光的技术，光声成像（派），通过高分辨率成像膀胱组织中的微血管诊断膀胱癌的潜力。离体犬膀胱的成像结果表明，派在光学散射膀胱组织中映射三维微血管系统的出色能力。通过对膀胱癌组织和正常膀胱组织的PAI检测结果的比较，探讨派在膀胱癌良恶性鉴别诊断中的可行性。肿瘤微血管的独特形态特征可以在来自癌症样品的图像中看到，这表明派可以允许在体内评估与膀胱癌的产生和进展密切相关的新血管生成。通过呈现膀胱组织中的表面下形态和生理信息，当以与常规内窥镜检查类似的方式进行时，派为改善膀胱癌的诊断、分期和治疗指导提供了机会。
We explored the potential of an emerging laser-based technology, photoacoustic imaging (PAI), for bladder cancer diagnosis through high resolution imaging of microvasculature in the bladder tissues. Imaging results from ex vivo canine bladders demonstrated the excellent ability of PAI in mapping three-dimensional microvasculature in optically scattering bladder tissues. By comparing the results from human bladder specimens affected by cancer to those from the normal control, the feasibility of PAI in differentiate malignant from benign bladder tissues was also explored. The distinctive morphometric characteristics of tumor microvasculature can be seen in the images from cancer samples, suggesting that PAI may allow in vivo assessment of neoangiogenesis that is closely associated with bladder cancer generation and progression. By presenting subsurface morphological and physiological information in bladder tissues, PAI, when performed in a similar way as in conventional endoscopy, provides an opportunity for improved diagnosis, staging and treatment guidance of bladder cancer.