Changes in the signal- and contrast-to-noise ratios of hepatocellular carcinomas on gadoxetic acid-enhanced dynamic MR imaging
Changes in the signal- and contrast-to-noise ratios of hepatocellular carcinomas on gadoxetic acid-enhanced dynamic MR imaging
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DOI：
10.1016/j.ejrad.2012.05.036
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发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Park, Cheol Keun
中科院分区：
文献类型：
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作者：
Kim, Hyun Su;Choi, Dongil;Park, Cheol Keun
目的：我们的目的是评估肝细胞癌（HCC）在钆塞酸增强MRI上的增强模式（通过信号（SNR）和对比噪声比（CNRs）的变化来测量）是否反映了肿瘤分化。285例患者，286例经手术证实的HCC，均接受了钆塞酸增强MRI检查（11例I级、267例II级、7例III级和1例IV级肿瘤）。采用T1加权三维快速场回波序列获得平扫和动态图像。结果：286个肿瘤中有282个（98.6%）的信噪比测量显示出波动模式（信噪比增加，然后减少，然后增加[或信噪比减少，然后增加，然后减少]）。SNR测量还显示动脉期的单峰SNR（1.0% [3/286]）和3分钟延迟图像（0.3% [1/286]），随后4个（1.4% [4/286]）II级肿瘤降低。几乎所有的肿瘤（88.1% [252/286]），9（81.8% [9/11]）I级，236例（88.4% [236/267]）II级，6例（85.7% [6/7]）III级，1例（100% [1/1]）IV级肿瘤显示最大绝对CNR，且为负值，最常见于延迟20 min图像（67.5% [170/252]）。其余34 286（11.9%）肿瘤显示最大的绝对CNRs与阳性values.Conclusion：无论肿瘤分级，最常见的表现是SNR与波动模式与时间和最大的绝对CNRs与负值，这是最常见的肝胆阶段。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Our objective was to evaluate whether the enhancement pattern, measured by changes in the signal- (SNRs) and contrast-to-noise ratios (CNRs), of hepatocellular carcinomas (HCCs) on gadoxetic acid-enhanced MRI reflects tumor differentiation.Subjects and methods: Two hundred eighty-five patients with 286 surgically-confirmed HCCs who underwent gadoxetic acid-enhanced MRI were included (11 grade I, 267 grade II, 7 grade III, and 1 grade IV tumor). Unenhanced and dynamic images with a T1-weighted 3D turbo-field-echo sequence were obtained. Relative signal intensities of the tumors with respect to surrounding liver were evaluated and the SNRs and CNRs were calculated.Results: SNR measurements demonstrated a fluctuating pattern (an increase in the SNR, followed by a decrease and a subsequent increase [or a decrease in the SNR followed by an increase and a subsequent decrease]) in 282 of 286 (98.6%) tumors. The SNR measurements also showed a single-peak SNR in the arterial phase (1.0% [3/286]) and 3 min delayed images (0.3% [1/286]) followed by a decrease in 4 (1.4% [4/286]) grade II tumors. Nearly all tumors (88.1% [252/286]), 9 (81.8% [9/11]) grade I, 236 (88.4% [236/267]) grade II, 6 (85.7% [6/7]) grade III, and 1 (100% [1/1]) grade IV tumor showed maximum absolute CNRs with negative values, which were most commonly found in 20 min delayed images (67.5% [170/252]). The remaining 34 of 286 (11.9%) tumors showed maximum absolute CNRs with positive values.Conclusion: Regardless of the tumor grades, the most common manifestation was a SNR with a fluctuating pattern with time and maximum absolute CNRs with negative values, which were most commonly noted in the hepatobiliary phase. (C) 2012 Elsevier Ireland Ltd. All rights reserved.