THE PHARMACOLOGY OF METHOTREXATE
THE PHARMACOLOGY OF METHOTREXATE
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DOI：
10.1016/0190-9622(91)70199-c
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发表时间：
1991-08-01
影响因子：
13.8
通讯作者：
OLSEN, EA
中科院分区：
文献类型：
--
作者：
OLSEN, EA
甲氨蝶呤是一种有用的抗代谢物，用于治疗良性和恶性增生性疾病。当药物的药代动力学和潜在毒性被了解后，治疗方案可以根据目标人群的潜在动力学进行调整。对甲氨蝶呤尿排泄的重要性和影响因素的适当认识，以及亚叶酸素的现成可用性，除了最不寻常的情况外，在所有情况下都可以避免毒性。
Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population. With the appropriate knowledge of the importance of urinary excretion of methotrexate and factors that influence this and with the ready availability of leucovorin, toxicity can be avoided in all but the most unusual of circumstances.