Susceptibility and resistance to Schistosoma mansoni reinfection:: Parallel cellular and isotypic immunologic assessment
Susceptibility and resistance to Schistosoma mansoni reinfection:: Parallel cellular and isotypic immunologic assessment
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DOI：
10.4269/ajtmh.2000.62.57
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发表时间：
2000-01-01
影响因子：
3.3
通讯作者：
Gazzinelli, G
中科院分区：
文献类型：
--
作者：
Caldas, IR;Correa-Oliveira, R;Gazzinelli, G
在化疗治愈后被认为对再感染敏感或具有抵抗力的个体中，评估了对曼氏血吸虫抗原制剂的细胞和体液免疫反应。在敏感组和耐药组中，治疗后观察到对可溶性卵抗原（SEA）的反应持续增殖增加。然而，这种变化与阻力无关。同型研究表明，耐药组中针对可溶性蠕虫抗原制剂（SWAP）和尾蚴抗原的IgM抗体水平显着高于易感组。治疗后，在耐药组中观察到 IgE 抗 SWAP 和抗血吸虫体皮 (STEG) 反应增加，而 IgG4 抗 SEA 和抗 STEG 反应减少。这些发现与我们之前报道的被称为地方性正常人的假定耐药群体的发现相似，并且与不同流行地区的免疫学研究相一致。总之，这些发现表明，即使在人群水平上，高 IgE 特异性加上低 IgG4 特异性也与记录的对再感染的抵抗力密切相关。
Cellular and humoral immune responses to Schistosoma mansoni antigen preparations were evaluated in individuals presumed to be susceptible or resistant to reinfection after chemotherapeutic cure. A consistent proliferative increase in the response to soluble egg antigen (SEA) was observed post-treatment in both the susceptible and resistant groups. However, this change was not related to resistance. Isotype studies showed that IgM antibody levels to soluble worm antigen preparation (SWAP) and cercariae antigens were significantly higher in the resistant group than in the susceptible group. Post-treatment, an increase in IgE anti-SWAP and anti-schistosomular tegument (STEG) responses and a decrease in IgG4 anti-SEA and anti-STEG responses were observed in the resistant group. These finding are similar to those we have reported previously for a putative resistant group termed endemic normals, and are compatible with immunologic studies in different endemic areas. Together, these findings indicate that even on the population level, high IgE specificities coupled with low IgG4 specificities correlate well with documented resistance to reinfection.