Damage segregation at fissioning may increase growth rates: A superprocess model
Damage segregation at fissioning may increase growth rates: A superprocess model
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DOI：
10.1016/j.tpb.2007.02.004
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发表时间：
2007-06-01
影响因子：
1.4
通讯作者：
Steinsaltz, David
中科院分区：
文献类型：
--
作者：
Evans, Steven N.;Steinsaltz, David
一个分裂的有机体可以通过优先将无法修复的损伤传给它的一个子代来清除这些损伤。使用数学形式主义的超过程，我们提出了一个灵活的类的分析听话的模型，允许相当一般的影响，损害的死亡率和分裂率和类似的一般损害隔离机制。我们表明，在一个合适的制度，在裂变损伤隔离的随机性的影响是不可区分的随机性的损伤积累的机制，在生物体的寿命。此外，最优的人口增长实现了一个特定的有限的，非零水平的组合随机性，从这两个来源。特别是，当损害累积确定性，最佳的人口增长是实现适度不平等的女儿之间的损害分工，而太少或太多的分工是次优的。连接都提请最近的实验结果在原生动物中的损伤遗传，以及兄弟姐妹之间的老化和资源分配的理论。(C)2007爱思唯尔公司All rights reserved.
A fissioning organism may purge unrepairable damage by bequeathing it preferentially to one of its daughters. Using the mathematical formalism of superprocesses, we propose a flexible class of analytically tractable models that allow quite general effects of damage on death rates and splitting rates and similarly general damage segregation mechanisms. We show that, in a suitable regime, the effects of randomness in damage segregation at fissioning are indistinguishable from those of randomness in the mechanism of damage accumulation during the organism's lifetime. Moreover, the optimal population growth is achieved for a particular finite, non-zero level of combined randomness from these two sources. In particular, when damage accumulates deterministically, optimal population growth is achieved by a moderately unequal division of damage between the daughters, while too little or too much division is sub-optimal. Connections are drawn both to recent experimental results on inheritance of damage in protozoans, and to theories of aging and resource division between siblings. (C) 2007 Elsevier Inc. All rights reserved.