A Wireless Fully Passive Neural Recording Device for Unobtrusive Neuropotential Monitoring
A Wireless Fully Passive Neural Recording Device for Unobtrusive Neuropotential Monitoring
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DOI：
10.1109/tbme.2015.2458583
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发表时间：
2016-01-01
影响因子：
4.6
通讯作者：
Volakis, John L.
中科院分区：
文献类型：
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作者：
Kiourti, Asimina;Lee, Cedric W. L.;Volakis, John L.
目标：我们提出了一种新型无线全被动神经记录设备，用于不引人注目的神经电位监测。先前的工作证明了以无线完全被动方式监测模拟大脑信号的可行性。在本文中，我们提出了一种新颖的现实录音机，其体积明显更小且更灵敏。方法：所提出的记录仪采用高效的微波反向散射方法，无需任何正式的电源或调节元件即可运行。此外，不需要颅内电线或电缆。体外测试是在四层头部模型（皮肤、骨骼、灰质和白质）内进行的。结果：与我们之前的实现相比，本研究中提出的神经记录器具有以下改进功能：1）占地面积缩小了 59%，2）神经电位检测灵敏度提高了 20 dB，3）封装在生物相容性聚合物中。结论：首次可以以无线全被动方式检测低至 63 mu V-pp 的时间模拟神经电位。值得注意的是，这项研究实现的高灵敏度意味着可以读取人脑产生的大多数神经信号。意义：所提出的记录器为无线全被动神经检测带来了变革的可能性，适用于非常广泛的应用（例如癫痫、阿尔茨海默病、精神障碍等）。
Goal: We propose a novel wireless fully passive neural recording device for unobtrusive neuropotential monitoring. Previous work demonstrated the feasibility of monitoring emulated brain signals in a wireless fully passive manner. In this paper, we propose a novel realistic recorder that is significantly smaller and much more sensitive. Methods: The proposed recorder utilizes a highly efficient microwave backscattering method and operates without any formal power supply or regulating elements. Also, no intracranial wires or cables are required. In-vitro testing is performed inside a four-layer head phantom (skin, bone, gray matter, and white matter). Results: Compared to our former implementation, the neural recorder proposed in this study has the following improved features: 1) 59% smaller footprint, 2) up to 20-dB improvement in neuropotential detection sensitivity, and 3) encapsulation in biocompatible polymer. Conclusion: For the first time, temporal emulated neuropotentials as low as 63 mu V-pp can be detected in a wireless fully passive manner. Remarkably, the high-sensitivity achieved in this study implies reading of most neural signals generated by the human brain. Significance: The proposed recorder brings forward transformational possibilities in wireless fully passive neural detection for a very wide range of applications (e.g., epilepsy, Alzheimer's, mental disorders, etc.).