THE DIFFERENT TISSUE TRANSCRIPTION PATTERNS OF GENES FOR HNF-1, C/EBP, HNF-3, AND HNF-4, PROTEIN FACTORS THAT GOVERN LIVER-SPECIFIC TRANSCRIPTION
THE DIFFERENT TISSUE TRANSCRIPTION PATTERNS OF GENES FOR HNF-1, C/EBP, HNF-3, AND HNF-4, PROTEIN FACTORS THAT GOVERN LIVER-SPECIFIC TRANSCRIPTION
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DOI：
10.1073/pnas.88.9.3807
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发表时间：
1991-05-01
影响因子：
11.1
通讯作者：
DARNELL, JE
中科院分区：
文献类型：
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作者：
XANTHOPOULOS, KG;PREZIOSO, VR;DARNELL, JE
参与肝细胞特异性基因表达的转录因子包括主要存在于肝细胞中的蛋白（HNF-1/LFB1、C/EBP、HNF-3、HNF-4） （HNF，肝细胞核因子；C/EBP，大鼠增强子结合蛋白）和广泛分布的蛋白（AP-1、NF-1、NF-Y/ACF）。我们在这里表明，编码这些肝脏富集因子的基因在不同的组织中表现出不同的转录控制模式。此外，在没有发现mRNA或特定DNA结合蛋白的情况下，也有几种情况下检测到转录（例如，对于HNF-1），这表明在某些情况下，转录后控制对这些因素的重要性。这些实验确定了C/EBP、HNF-3和HNF-4，可能还有HNF-1，作为分化细胞中转录控制转录因子级联研究的靶点。
The transcription factors that act in hepatocyte-specific gene expression include proteins that are present mainly in liver cells (HNF-1/LFB1, C/EBP, HNF-3, HNF-4) (HNF, hepatocyte nuclear factor; C/EBP, rat enhancer binding protein) and proteins that are widely distributed (AP-1, NF-1, NF-Y/ACF). We show here that the genes encoding each of these liver-enriched factors exhibit different patterns of transcriptional control in different tissues. In addition, there were several instances in which transcription was detected (e.g., for HNF-1) when no mRNA or specific DNA binding protein was found, suggesting the importance of posttranscriptional control in some instances for these factors. These experiments identify C/EBP, HNF-3, and HNF-4, and perhaps also HNF-1, as targets for the study of cascades of transcriptionally controlled transcription factors in differentiated cells.