Enhancing effect of essential oils on the penetration of 5-fluorouracil through rat skin.
Enhancing effect of essential oils on the penetration of 5-fluorouracil through rat skin.
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发表时间：
1996
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通讯作者：
D. Abdullah;Ping Qn;Liu Gj
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作者：
D. Abdullah;Ping Qn;Liu Gj
用大鼠离体皮研究了3种精油作为5-氟尿嘧啶(5-FU)透皮促进剂的作用。使用的油是桉树、薄荷和松节油。用氮酮作对照。油剂对5-FU的促渗作用弱于氮酮，但均能促进5-FU的渗透。桉树油的活性最强，约增加60倍，薄荷油和松节油分别增加46倍和28倍。对桉树油进行了进一步的研究，根据沸点的不同将桉树油分为5个级分。结果表明，它们的活性随沸点的升高而增加。随着所有促进剂的加入，分配系数增大，但扩散系数值相对较大。这些促进剂的作用方式可以用分配过程和扩散过程相结合来描述，其中扩散过程占主导地位。
Three essential oils as penetration enhancers for 5-fluorouracil (5-FU) were studied using excised rat skin. The oils used were eucalyptus, peppermint and turpentine. Azone was used for comparison. The enhancing effect of the oils was found to be less than that of azone, but all the oils used enhanced the permeation of 5-FU. Eucalyptus oil was found to be the most active, causing about 60 fold increase, while peppermint and turpentine caused 46 and 28 fold increase, respectively. Eucalyptus oil was further studied by grading it into 5 fractions according to difference in boiling points. It was found that their activities increased as their boiling point increased. With all enhancers increased partition coefficients were observed but the diffusion coefficient values obtained were comparatively higher. The mode of action of these accelerants may be described by combined processes of partition and diffusion, the diffusion process being dominant.